dc.contributor.author | Oberg, Christopher T | |
dc.contributor.author | Blanchard, Helen | |
dc.contributor.author | Leffler, Hakon | |
dc.contributor.author | Nilsson, Ulf J | |
dc.date.accessioned | 2017-05-03T14:15:04Z | |
dc.date.available | 2017-05-03T14:15:04Z | |
dc.date.issued | 2008 | |
dc.date.modified | 2011-06-09T22:41:13Z | |
dc.identifier.issn | 0960-894X | |
dc.identifier.doi | 10.1016/j.bmcl.2008.05.066 | |
dc.identifier.uri | http://hdl.handle.net/10072/21598 | |
dc.description.abstract | A series of O2 and O3-derivatized methyl ߭d-talopyranosides were synthesized and evaluated in vitro as inhibitors of the galactose-binding galectin-1, -2, -3, -4 (N- and C-terminal domains), 8 (N-terminal domain), and 9 (N-terminal domain). Galectin-4C and 8N were found to prefer the d-talopyranose configuration to the natural ligand d-galactopyranose configuration. Derivatization at talose O2 and/or O3 provided selective submillimolar inhibitors for these two galectins. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 3691 | |
dc.relation.ispartofpageto | 3694 | |
dc.relation.ispartofissue | 13 | |
dc.relation.ispartofjournal | Bioorganic and Medicinal Chemistry Letters | |
dc.relation.ispartofvolume | 18 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.title | Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8 | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2008 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Blanchard, Helen | |