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dc.contributor.authorOberg, Christopher T
dc.contributor.authorBlanchard, Helen
dc.contributor.authorLeffler, Hakon
dc.contributor.authorNilsson, Ulf J
dc.date.accessioned2017-05-03T14:15:04Z
dc.date.available2017-05-03T14:15:04Z
dc.date.issued2008
dc.date.modified2011-06-09T22:41:13Z
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2008.05.066
dc.identifier.urihttp://hdl.handle.net/10072/21598
dc.description.abstractA series of O2 and O3-derivatized methyl ߭d-talopyranosides were synthesized and evaluated in vitro as inhibitors of the galactose-binding galectin-1, -2, -3, -4 (N- and C-terminal domains), 8 (N-terminal domain), and 9 (N-terminal domain). Galectin-4C and 8N were found to prefer the d-talopyranose configuration to the natural ligand d-galactopyranose configuration. Derivatization at talose O2 and/or O3 provided selective submillimolar inhibitors for these two galectins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3691
dc.relation.ispartofpageto3694
dc.relation.ispartofissue13
dc.relation.ispartofjournalBioorganic and Medicinal Chemistry Letters
dc.relation.ispartofvolume18
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode0305
dc.titleProtein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorBlanchard, Helen


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