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dc.contributor.authorBeckhouse, Anthony
dc.contributor.authorM. Grant, Chris
dc.contributor.authorJ. Rogers, Peter
dc.contributor.authorW. Dawes, Ian
dc.contributor.authorJ. Higgins, Vincent
dc.date.accessioned2017-05-03T15:18:38Z
dc.date.available2017-05-03T15:18:38Z
dc.date.issued2008
dc.date.modified2009-03-26T06:41:48Z
dc.identifier.issn15671356
dc.identifier.doi10.1111/j.1567-1364.2008.00439.x
dc.identifier.urihttp://hdl.handle.net/10072/21624
dc.description.abstractThe molecular mechanisms involved in the ability of cells to adapt and respond to differing oxygen tensions are of great interest to the pharmaceutical, medical and fermentation industries. The transcriptional profiles reported in previous studies of cells grown under anaerobic, aerobic and dynamic growth conditions have shown significantly altered responses including induction of genes regulated by the oxidative stress transcription factor Yap1p when oxygen was present. The present study investigated the phenotypic changes that occur in cells when shifted from anaerobic to aerobic growth conditions and it was found through mutant analyses that the elevated activity of Yap1p during the shift was mediated by the phospholipid hydroperoxide-sensing protein encoded by GPX3. Cell viability and growth rate were unaffected even though anaerobically grown cells were found to be hypersensitive to low doses of the oxidative stress-inducing compound hydrogen peroxide (H2O2). Adaptation to H2O2 treatment was demonstrated to occur when anaerobically grown wild-type cells were aerated for a short time that was reliant on the Yap1p and Skn7p transcription factors.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent165589 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Ltd.
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://www.wiley.com/bw/journal.asp?ref=1567-1356
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1214
dc.relation.ispartofpageto1222
dc.relation.ispartofjournalFEMS Yeast Research
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode09
dc.subject.fieldofresearchcode10
dc.titleThe adaptive response of anaerobically grown Saccharomyces cerevisiae to hydrogen peroxide is mediated by the Yap1and Skn7 transcription factors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2008 Wiley-Blackwell Publishing. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher. The definitive version is available at www.interscience.wiley.com
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorBeckhouse, Anthony G.


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