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dc.contributor.authorLoudoun, Rebecca
dc.contributor.editorProfessor J Wilson, Professor j Parsons
dc.date.accessioned2017-05-03T14:12:11Z
dc.date.available2017-05-03T14:12:11Z
dc.date.issued2008
dc.date.modified2009-03-12T06:33:24Z
dc.identifier.issn0003-6870
dc.identifier.doi10.1016/j.apergo.2007.12.004
dc.identifier.urihttp://hdl.handle.net/10072/21664
dc.description.abstractAmounts of ߁-activin, ߃-activin, activin receptor subunits ActRIIA and ActRIIB mRNA, and ߁- and ߃-activin subunit protein immunoreactivity were investigated in male Lewis rats, either untreated or after 5 or 10 weeks of CCl4 treatment to induce cirrhosis. Apoptosis was assessed histologically and with an in situ cell death detection kit (TUNEL). Reverse transcription and polymerase chain reaction were used to evaluate mRNA levels. Activin ߁- and ߃-subunit immunoreactivity was studied by immunohistochemistry using specific monoclonal antibodies. Hepatocellular apoptosis (P<0.001), increased ߁- and ߃-activin mRNAs (three- to fourfold; P<0.01) and increased ߁- and ߃-activin tissue immunoreactivity were evident, whereas ActRIIA mRNA concentrations fell (30%; P<0.01) after 5 weeks of CCl4 treatment. The mRNA concentrations at 10 weeks were not significantly different from controls, despite extensive hepatic nodule formation. We conclude that the increased activin subunit expression is associated with apoptosis, rather than hepatic fibrosis and nodule formation.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent142030 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUK
dc.publisher.urihttp://www.elsevier.com/locate/mce
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom572
dc.relation.ispartofpageto579
dc.relation.ispartofissue5
dc.relation.ispartofjournalApplied Ergonomics
dc.relation.ispartofvolume39
dc.rights.retentionY
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchDesign
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode3303
dc.titleBalancing shiftwork and life outside work: Do 12-h shifts make a difference?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Business School, Dept of Employment Relations and Human Resources
gro.rights.copyright© 2008 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorLoudoun, Rebecca J.


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