Show simple item record

dc.contributor.authorLoudoun, Rebeccaen_US
dc.contributor.editorProfessor J Wilson, Professor j Parsonsen_US
dc.date.accessioned2017-04-24T11:27:18Z
dc.date.available2017-04-24T11:27:18Z
dc.date.issued2008en_US
dc.date.modified2009-03-12T06:33:24Z
dc.identifier.issn0003-6870en_US
dc.identifier.doi10.1016/j.apergo.2007.12.004en_AU
dc.identifier.urihttp://hdl.handle.net/10072/21664
dc.description.abstractAmounts of ߁-activin, ߃-activin, activin receptor subunits ActRIIA and ActRIIB mRNA, and ߁- and ߃-activin subunit protein immunoreactivity were investigated in male Lewis rats, either untreated or after 5 or 10 weeks of CCl4 treatment to induce cirrhosis. Apoptosis was assessed histologically and with an in situ cell death detection kit (TUNEL). Reverse transcription and polymerase chain reaction were used to evaluate mRNA levels. Activin ߁- and ߃-subunit immunoreactivity was studied by immunohistochemistry using specific monoclonal antibodies. Hepatocellular apoptosis (P<0.001), increased ߁- and ߃-activin mRNAs (three- to fourfold; P<0.01) and increased ߁- and ߃-activin tissue immunoreactivity were evident, whereas ActRIIA mRNA concentrations fell (30%; P<0.01) after 5 weeks of CCl4 treatment. The mRNA concentrations at 10 weeks were not significantly different from controls, despite extensive hepatic nodule formation. We conclude that the increased activin subunit expression is associated with apoptosis, rather than hepatic fibrosis and nodule formation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent142030 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUKen_US
dc.publisher.urihttp://www.elsevier.com/locate/mceen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom572en_US
dc.relation.ispartofpageto579en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalApplied Ergonomicsen_US
dc.relation.ispartofvolume39en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode350203en_US
dc.titleBalancing shiftwork and life outside work: Do 12-h shifts make a difference?en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Business School, Dept of Employment Relations and Human Resourcesen_US
gro.rights.copyrightCopyright 2008 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2008
gro.hasfulltextFull Text


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record