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  • Exploration of the Cell-Cycle Genes Found Within the RIKEN FANTOM2 Data Set

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    Author
    Forrest, Alistair R. R.
    Taylor, Darrin
    RIKEN GER Group, None
    Genome Science Laboratory (GSL), None
    Grimmond, Sean
    Year published
    2003
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    Abstract
    The cell cycle is one of the most fundamental processes within a cell. Phase-dependent expression and cell-cycle checkpoints require a high level of control. A large number of genes with varying functions and modes of action are responsible for this biology. In a targeted exploration of the FANTOM2-Variable Protein Set, a number of mouse homologs to known cell-cycle regulators as well as novel members of cell-cycle families were identified. Focusing on two prototype cell-cycle families, the cyclins and the NIMA-related kinases (NEKs), we believe we have identified all of the mouse members of these families, 24 cyclins and 10 NEKs, and mapped them to ENSEMBL transcripts. To attempt to globally identify all potential cell cycle-related genes within mouse, the MGI (Mouse Genome Database) assignments for the RIKEN Representative Set (RPS) and the results from two homology-based queries were merged. We identified 1415 genes with possible cell-cycle roles, and 1758 potential paralogs. We comment on the genes identified in this screen and evaluate the merits of each approach.
    Journal Title
    Genome Research
    Volume
    13
    Issue
    6B
    DOI
    https://doi.org/10.1101/gr.1012403
    Copyright Statement
    © 2003 Cold Spring Harbor Laboratory Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Publication URI
    http://hdl.handle.net/10072/21723
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