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dc.contributor.authorRavasi, Timothy
dc.contributor.authorHuber, Thomas
dc.contributor.authorZavolan, Mihaela
dc.contributor.authorForrest, Alistair
dc.contributor.authorGaasterland, Terry
dc.contributor.authorGrimmond, Sean
dc.contributor.authorGroup, RIKEN GER
dc.contributor.authorMembers, GSL
dc.contributor.authorA. Hume, David
dc.date.accessioned2017-09-06T00:28:16Z
dc.date.available2017-09-06T00:28:16Z
dc.date.issued2003
dc.identifier.issn10889051
dc.identifier.doi10.1101/gr.949803
dc.identifier.urihttp://hdl.handle.net/10072/21724
dc.description.abstractZinc-finger-containing proteins can be classified into evolutionary and functionally divergent protein families that share one or more domains in which a zinc ion is tetrahedrally coordinated by cysteines and histidines. The zinc finger domain defines one of the largest protein superfamilies in mammalian genomes;46 different conserved zinc finger domains are listed in InterPro (http://www.ebi.ac.uk/InterPro). Zinc finger proteins can bind to DNA, RNA, other proteins, or lipids as a modular domain in combination with other conserved structures. Owing to this combinatorial diversity, different members of zinc finger superfamilies contribute to many distinct cellular processes, including transcriptional regulation, mRNA stability and processing, and protein turnover. Accordingly, mutations of zinc finger genes lead to aberrations in a broad spectrum of biological processes such as development, differentiation, apoptosis, and immunological responses. This study provides the first comprehensive classification of zinc finger proteins in a mammalian transcriptome. Specific detailed analysis of the SP/Kr찰el-like factors and the E3 ubiquitin-ligase RING-H2 families illustrates the importance of such an analysis for a more comprehensive functional classification of large protein families. We describe the characterization of a new family of C2H2 zinc-finger-containing proteins and a new conserved domain characteristic of this family, the identification and characterization of Sp8, a new member of the Sp family of transcriptional regulators, and the identification of five new RING-H2 proteins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCold Spring Harbor Laboratory Press, Publications Department
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1430
dc.relation.ispartofpageto1442
dc.relation.ispartofissue6B
dc.relation.ispartofjournalGenome Research
dc.relation.ispartofvolume13
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleSystematic characterization of the zinc-finger-containing proteins in the mouse transcriptome
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2003 Cold Spring Harbor Laboratory Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2015-06-03T02:22:48Z
gro.hasfulltextFull Text
gro.griffith.authorForrest, Alistair RR.


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