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dc.contributor.authorYuen, APW
dc.contributor.authorLam, KY
dc.contributor.authorChoy, JTH
dc.contributor.authorHo, WK
dc.contributor.authorWong, LY
dc.contributor.authorWei, WI
dc.contributor.editorD Rew
dc.date.accessioned2017-05-03T14:35:43Z
dc.date.available2017-05-03T14:35:43Z
dc.date.issued2002
dc.date.modified2009-03-18T07:22:17Z
dc.identifier.issn0748-7983
dc.identifier.doi10.1053/ejso.2002.1287
dc.identifier.urihttp://hdl.handle.net/10072/21786
dc.description.abstractAim: There is still controversy on the incidence of positive expression of bcl-2 and its prognostic significance for oral tongue carcinoma patients who are treated by surgery. The present study aims at resolving the controversy on the clinicopathologic significance of bcl-2 in a well selected group of patients who satisfy the recruitment criteria: (1) oral tongue carcinoma, (2) squamous cell carcinoma, (3) primary surgical treatment. Method: Bcl-2 expression was studied by immunohistochemistry on glossectomy specimens of 73 patients. The expression of bcl-2 was correlated with clinicopathologic data. Results: Of the 73 tumours, 11% had positive expression of bcl-2. Bcl-2 expression was not significantly correlated with tumour grade, stage, nodal metastasis and survival. Conclusion: Bcl-2 expression played a minor role in oral tongue carcinoma. It had no significant correlation with tumour grade, stage and nodal metastasis. It also had no prognostic value on survival for patients who were treated by primary surgery.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherW.B. Saunders Co. Ltd.
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://www.sciencedirect.com/science/journal/07487983
dc.relation.ispartofpagefrom667
dc.relation.ispartofpageto672
dc.relation.ispartofissue6
dc.relation.ispartofjournalEuropean Journal of Surgical Oncology
dc.relation.ispartofvolume28
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.titleClinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2002
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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