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dc.contributor.authorWu, YH
dc.contributor.authorLiew, AWC
dc.contributor.authorYan, H
dc.contributor.authorYang, MS
dc.date.accessioned2017-05-03T15:20:24Z
dc.date.available2017-05-03T15:20:24Z
dc.date.issued2003
dc.date.modified2009-10-16T05:19:48Z
dc.identifier.issn0009-2614
dc.identifier.doi10.1016/S0009-2614(02)01684-6
dc.identifier.urihttp://hdl.handle.net/10072/21796
dc.description.abstractThe large number of bases in a DNA sequence and the cryptic nature of the 4-alphabet representation make graphical visualization of DNA sequences useful for biologists. However, existing 3D graphical representations are complicated, whereas existing 2D graphical representations suffer from high degeneracy, and many features in a DNA sequence cannot be visualized clearly. This Letter introduces a novel 2D method of DNA representation: the DB-Curve (Dual-Base Curve), which overcomes some of the limitations in existing 2D graphical representations. Many properties of DNA sequences can be observed and visualized easily using a combination of DB-Curves. The new representation can avoid degeneracy completely compared to existing 2D graphical representations of DNA sequences. Unlike 3D graphical representations, no 2D projection is required for the DB-Curve, and this allows for easier analysis of DNA sequences. The DB-Curve provides a useful graphical tool for the visualization and study of DNA sequences.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/505707/description#description
dc.relation.ispartofpagefrom170
dc.relation.ispartofpageto176
dc.relation.ispartofissue1-2
dc.relation.ispartofjournalChemical Physics Letters
dc.relation.ispartofvolume367
dc.subject.fieldofresearchPhysical sciences
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchcode51
dc.subject.fieldofresearchcode34
dc.titleDB-Curve: A novel 2D method of DNA sequence visualization and representation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorLiew, Alan Wee-Chung


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