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dc.contributor.authorLam, KY
dc.contributor.authorLeung, PS
dc.contributor.editorPaolo Beck-Peccoz
dc.date.accessioned2017-05-03T14:35:42Z
dc.date.available2017-05-03T14:35:42Z
dc.date.issued2002
dc.date.modified2009-03-24T06:39:43Z
dc.identifier.issn0804-4643
dc.identifier.doi10.1530/eje.0.1460567
dc.identifier.urihttp://hdl.handle.net/10072/21842
dc.description.abstractOBJECTIVE: Evidence exists for the presence of a renin-angiotensin system (RAS) in the pancreas. The aims of this study were to prove the presence of an intrinsic RAS in the human pancreas and to analyse the role of such an RAS in pancreatic endocrine tumours (PETs). METHODS: Gene expression of key RAS components (angiotensinogen and angiotensin II receptors, namely AT1 and AT2) was investigated in human pancreas and in PETs by semi-quantitative RT-PCR and immunohistochemistry. RESULTS: Expression of mRNAs of RAS components was found in human pancreas and in PETs. Data from semi-quantitative RT-PCR analysis demonstrated an increase in the mRNA expression of angiotensinogen and AT2 receptor in PETs when compared with that in normal pancreas. By immunohistochemistry, angiotensinogen protein was predominantly localized in the pancreatic islets while AT1 receptor protein was in the pancreatic ducts. CONCLUSIONS: The data support the notion of the existence of an intrinsic RAS in the human pancreas. It also indicates, for the first time, that such a local pancreatic RAS is subject to regulation by PETs and its significant change may have pathophysiological relevance in patients with PETs.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioScientifica
dc.publisher.placeUK
dc.relation.ispartofpagefrom567
dc.relation.ispartofpageto572
dc.relation.ispartofissue4
dc.relation.ispartofjournalEuropean Journal of Endocrinology
dc.relation.ispartofvolume146
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleRegulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumours
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2002
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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