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dc.contributor.authorZhao, Po
dc.contributor.authorLam, Alfred King Yin
dc.contributor.authorLu, Ya-Li
dc.contributor.authorZhong, Mei
dc.contributor.authorChen, Ling-Hong
dc.contributor.authorPu, Xiao-Lu
dc.contributor.editorC Soon Lee
dc.date.accessioned2017-05-03T14:35:49Z
dc.date.available2017-05-03T14:35:49Z
dc.date.issued2006
dc.date.modified2009-03-24T06:39:54Z
dc.identifier.issn0031-3025
dc.identifier.doi10.1080/00313020600922512
dc.identifier.urihttp://hdl.handle.net/10072/21846
dc.description.abstractAims: The fragile histidine triad (FHIT) gene is frequently inactivated in human cancers; however, the FHIT gene remains unexplored in Hodgkin's lymphoma. The aim of this study was to investigate the role of FHIT expression in classical Hodgkin's lymphoma. Methods: Classical Hodgkin's lymphomas were analysed for FHIT gene expression by two-step non-biotin immunohistochemical method and Western blotting. Results: Thirty of the 33 (91%) cases of Hodgkin's lymphoma tested were positive for FHIT protein by immuohistochemistry. The expression of FHIT was mainly located in cytoplasm of Reed-Sternberg (HRS) cells. The protein expression was also documented by Western blotting. The non-Hodgkin's lymphomas were negative for FHIT protein. Conclusions: The results indicate that abnormal FHIT expression is noted frequently in classical Hodgkin's lymphoma and the expression can give insight into the pathogenesis of the disease. The protein may serve as a marker to localise HRS cells in classical Hodgkin's lymphoma.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherThe Royal College of Pathologists of Australasia
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom399
dc.relation.ispartofpageto402
dc.relation.ispartofissue5
dc.relation.ispartofjournalPathology
dc.relation.ispartofvolume38
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleAberrant FHIT protein expression in classical Hodgkin's lymphoma: a potential marker
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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