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dc.contributor.authorNolan, Daniel J.
dc.contributor.authorCiarrocchi, Alessia
dc.contributor.authorMellick, Albert S.
dc.contributor.authorJaggi, Jaspreet S.
dc.contributor.authorBambino, Kathryn
dc.contributor.authorGupta, Sunita
dc.contributor.authorHeikamp, Emily
dc.contributor.authorMcDevitt, Michael R.
dc.contributor.authorScheinberg, David A.
dc.contributor.authorBenezra, Robert
dc.contributor.authorMittal, Vivek
dc.contributor.editorT. Grodzicker
dc.date.accessioned2017-05-03T16:55:25Z
dc.date.available2017-05-03T16:55:25Z
dc.date.issued2007
dc.date.modified2009-09-04T06:06:18Z
dc.identifier.issn08909369
dc.identifier.doi10.1101/gad.436307
dc.identifier.urihttp://hdl.handle.net/10072/21851
dc.description.abstractTumors build vessels by cooption of pre-existing vasculature and de novo recruitment of bone marrow (BM)-derived endothelial progenitor cells (EPCs). However, the contribution and the functional role of EPCs in tumor neoangiogenesis are controversial. Therefore, by using genetically marked BM progenitor cells, we demonstrate the precise spatial and temporal contribution of EPCs to the neovascularization of three transplanted and one spontaneous breast tumor in vivo using high-resolution microscopy and flow cytometry. We show that early tumors recruit BM-derived EPCs that differentiate into mature BM-derived endothelial cells (ECs) and luminally incorporate into a subset of sprouting tumor neovessels. Notably, in later tumors, these BM-derived vessels are diluted with non-BM-derived vessels from the periphery, which accounts for purported differences in previously published reports. Furthermore, we show that specific ablation of BM-derived EPCs with -particle-emitting anti-VE-cadherin antibody markedly impaired tumor growth associated with reduced vascularization. Our results demonstrate that BM-derived EPCs are critical components of the earliest phases of tumor neoangiogenesis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCold Spring Harbor Laboratory Press
dc.publisher.placeUnited States
dc.publisher.urihttp://genesdev.cshlp.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1546
dc.relation.ispartofpageto1558
dc.relation.ispartofissue12
dc.relation.ispartofjournalGenes & Development
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchCancer Genetics
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode111203
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleBone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, Albert S.


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