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dc.contributor.authorLam, KY
dc.contributor.authorLo, CY
dc.contributor.authorLeung, PS
dc.contributor.editorPaolo Beck-Peccoz
dc.date.accessioned2017-05-03T14:35:41Z
dc.date.available2017-05-03T14:35:41Z
dc.date.issued2002
dc.identifier.issn0804-4643
dc.identifier.doi10.1530/eje.0.1470741
dc.identifier.urihttp://hdl.handle.net/10072/21854
dc.description.abstractOBJECTIVE: The activation of RET proto-oncogene, through different types of chromosomal translocation and inversion, is unique to papillary thyroid carcinomas (PTC) and its frequency is variable in different populations. The aim of this study was to investigate the frequency and types of PTC genetic rearrangements in papillary carcinoma in a population of Hong Kong Chinese. METHODS: The presence of RET/PTC1, RET/PTC2 and RET/PTC3 activation was analyzed by RT-PCR in twenty PTC from adult patients (age range 24-63 years), one PTC from a 12-year-old boy and anaplastic carcinomas in two adult patients. RESULTS: RET/PTC3 was the only activation of RET proto-oncogene identified in the samples. Seventeen PTC from adult patients (85%t) were positive for RET/PTC3. RET/PTC3 was also identified in PTC from the child and one of the two patients with anaplastic thyroid carcinoma. CONCLUSIONS: The prevalence of RET/PTC activation in PTC is high and RET/PTC3 is the only type of activation identified in Hong Kong Chinese and is an important genetic event underlying the development of PTC in the population.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioScientifica
dc.publisher.placeUK
dc.relation.ispartofpagefrom741
dc.relation.ispartofpageto745
dc.relation.ispartofissue6
dc.relation.ispartofjournalEuropean Journal of Endocrinology
dc.relation.ispartofvolume147
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleHigh prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-06-05T04:19:27Z
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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