dc.contributor.author | M. Aumann, Kylee | |
dc.contributor.author | J. Scammells, Peter | |
dc.contributor.author | M. White, Jonathan | |
dc.contributor.author | H. Schiesser, Carl | |
dc.date.accessioned | 2017-05-03T15:25:19Z | |
dc.date.available | 2017-05-03T15:25:19Z | |
dc.date.issued | 2007 | |
dc.date.modified | 2009-03-26T06:42:38Z | |
dc.identifier.issn | 14770520 | |
dc.identifier.doi | 10.1039/b700812k | |
dc.identifier.uri | http://hdl.handle.net/10072/21913 | |
dc.description.abstract | Ethyl-2-amino-4,5,6,7-tetrahydro-1-benzoselenophene-3-carboxylate (4), has been prepared as a potential dual-acting selenium-containing allosteric enhancer of adenosine A1A receptor binding utilising a modified Gewald reaction. While preliminary testing indicated that 4 is a superior enhancer of A1AR binding than its thiophene counterpart, its instability under mildly acidic conditions is cause for concern. X-Ray crystallography, together with DFT calculations, provide evidence that the decomposition of 4 involves the ring-opening of selenophenium ion (12b) followed by the loss of elemental selenium through a radical chain process. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | The Royal Society of Chemistry | |
dc.publisher.place | Cambridge, UK | |
dc.publisher.uri | http://www.rsc.org/ | |
dc.relation.ispartofstudentpublication | Y | |
dc.relation.ispartofpagefrom | 1276 | |
dc.relation.ispartofpageto | 1281 | |
dc.relation.ispartofissue | 8 | |
dc.relation.ispartofjournal | Organic and Biomolecular Chemistry | |
dc.relation.ispartofvolume | 5 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and Biomolecular Chemistry | |
dc.subject.fieldofresearch | Organic Chemistry | |
dc.subject.fieldofresearchcode | 0304 | |
dc.subject.fieldofresearchcode | 0305 | |
dc.title | On the stability of 2-aminoselenophene-3-carboxylates: potential dual-acting selenium-containing allosteric enhancers of A1 adenosine receptor binding | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2007 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Aumann, Kylee M. | |