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dc.contributor.authorStenslokken, Kare-Olaven_US
dc.contributor.authorL. Milton, Sarahen_US
dc.contributor.authorL. Lutz, Peteren_US
dc.contributor.authorSundin, lenaen_US
dc.contributor.authorRenshaw, Gillianen_US
dc.contributor.authorA. W. Stecyk, Jonathanen_US
dc.contributor.authorE. Nilsson, Goranen_US
dc.contributor.editorPatrick J. Walsh (Editor-in-Chief), Thomas P Mommsen (Editor-in-Chief)en_US
dc.description.abstractTo survive anoxia, neural ATP levels have to be defended. Reducing electrical activity, which accounts for 50% or more of neural energy consumption, should be beneficial for anoxic survival. The retina is a hypoxia sensitive part of the central nervous system. Here, we quantify the in vivo retinal light response (electroretinogram; ERG) in three vertebrates that exhibit varying degrees of anoxia tolerance: freshwater turtle (Trachemys scripta), epaulette shark (Hemiscyllium ocellatum) and leopard frog (Rana pipiens). A virtually total suppression of ERG in anoxia, probably resulting in functional blindness, has previously been seen in the extremely anoxia-tolerant crucian carp (Carassius carassius). Surprisingly, the equally anoxiatolerant turtle, which strongly depresses brain and whole-body metabolism during anoxia, exhibited a relatively modest anoxic reduction in ERG: the combined amplitude of turtle ERG waves was reduced by ~50% after 2 h. In contrast, the shark b-wave amplitude practically disappeared after 30 min of severe hypoxia, and the frog b-wave was decreased by ~75% after 40 min in anoxia. The specific A1 adenosine receptor antagonist CPT significantly delayed the suppression of turtle ERG, while the hypoxic shark ERG was unaffected by the non-specific adenosine receptor antagonist aminophylline, suggesting adenosinergic involvement in turtle but not in shark.en_US
dc.publisher.placeAmsterdam, The Netherlands,en_US
dc.relation.ispartofjournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiologyen_US
dc.subject.fieldofresearchBiological Adaptationen_US
dc.titleEffect of anoxia on the electroretinogram of three anoxia-tolerant vertebratesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2008 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_AU
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