The effect of exercise on innate mucosal immunity

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Author(s)
West, NP
Pyne, DB
Kyd, JM
Renshaw, GM
Fricker, PA
Cripps, AW
Year published
2010
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We conducted a prospective observational study comparing salivary lactoferrin and lysozyme concentration over five months (chronic changes) in elite rowers (n=17, mean age 24.3 ᠴ.0y) with sedentary individuals (controls) (n=18, mean age = 27.2 ᠷ.1 y) and a graded exercise test to exhaustion (acute changes) with a cohort of elite rowers (n=11, mean age 24.7 ᠴ.1). Magnitudes of differences and changes were interpreted as a standardized (Cohen's) effect size (ES). Lactoferrin concentration in the observational study was approximately 60% lower in rowers than control subjects at baseline (7.9 ᠱ.2 姮ml-1 mean ᠓EM, 19.4 ᠵ.6 ...
View more >We conducted a prospective observational study comparing salivary lactoferrin and lysozyme concentration over five months (chronic changes) in elite rowers (n=17, mean age 24.3 ᠴ.0y) with sedentary individuals (controls) (n=18, mean age = 27.2 ᠷ.1 y) and a graded exercise test to exhaustion (acute changes) with a cohort of elite rowers (n=11, mean age 24.7 ᠴ.1). Magnitudes of differences and changes were interpreted as a standardized (Cohen's) effect size (ES). Lactoferrin concentration in the observational study was approximately 60% lower in rowers than control subjects at baseline (7.9 ᠱ.2 姮ml-1 mean ᠓EM, 19.4 ᠵ.6 姮ml-1, P=0.05, ES=0.68, 'moderate') and at the midpoint of the season (6.4 ᠱ.4 姮ml-1 mean ᠓EM, 21.5 ᠴ.2 姮ml-1, P=0.001, ES=0.89, 'moderate'). The concentration of lactoferrin at the end of the study was not statistically significant (P=0.1) between the groups. There was no significant difference between rowers and control subjects in lysozyme concentration during the study. There was a 50% increase in the concentration of lactoferrin (P=0.05, ES=1.04, 'moderate') and 55% increase in lysozyme (P=0.01, ES=3.0, 'very large') from pre-exercise to exhaustion in the graded exercise session. Lower concentrations of these proteins may be indicative of an impairment of innate protection of the upper respiratory tract. Increased salivary lactoferrin and lysozyme concentration following exhaustive exercise may be due to a transient activation response that increases protection in the immediate post exercise period.
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View more >We conducted a prospective observational study comparing salivary lactoferrin and lysozyme concentration over five months (chronic changes) in elite rowers (n=17, mean age 24.3 ᠴ.0y) with sedentary individuals (controls) (n=18, mean age = 27.2 ᠷ.1 y) and a graded exercise test to exhaustion (acute changes) with a cohort of elite rowers (n=11, mean age 24.7 ᠴ.1). Magnitudes of differences and changes were interpreted as a standardized (Cohen's) effect size (ES). Lactoferrin concentration in the observational study was approximately 60% lower in rowers than control subjects at baseline (7.9 ᠱ.2 姮ml-1 mean ᠓EM, 19.4 ᠵ.6 姮ml-1, P=0.05, ES=0.68, 'moderate') and at the midpoint of the season (6.4 ᠱ.4 姮ml-1 mean ᠓EM, 21.5 ᠴ.2 姮ml-1, P=0.001, ES=0.89, 'moderate'). The concentration of lactoferrin at the end of the study was not statistically significant (P=0.1) between the groups. There was no significant difference between rowers and control subjects in lysozyme concentration during the study. There was a 50% increase in the concentration of lactoferrin (P=0.05, ES=1.04, 'moderate') and 55% increase in lysozyme (P=0.01, ES=3.0, 'very large') from pre-exercise to exhaustion in the graded exercise session. Lower concentrations of these proteins may be indicative of an impairment of innate protection of the upper respiratory tract. Increased salivary lactoferrin and lysozyme concentration following exhaustive exercise may be due to a transient activation response that increases protection in the immediate post exercise period.
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Journal Title
British Journal of Sports Medicine
Volume
44
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Copyright Statement
© The Author(s) 2008. The attached file is posted here with permission of the copyright owners for your personal use only. No further distribution permitted. For information about this journal please refer to the publisher's website or contact the authors.
Subject
Innate Immunity
Engineering
Medical and Health Sciences
Education