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  • α-Tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis

    Author(s)
    Alleva, Renata
    Benassi, Maria Serena
    Pazzaglia, Laura
    Tomasetti, Marco
    Gellert, Nina
    Borghi, Battista
    Neuzil, Jiri
    Picci, Piero
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2006
    Metadata
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    Abstract
    a-Tocopheryl succinate (a-TOS) exerts pleiotrophic responses in malignant cells leading to cell cycle arrest, differentiation and apoptosis. We tested the ability of a-TOS to induce apoptosis or cell cycle perturbation in three human osteosarcoma (OS) cell lines which differ in their pRB and p53 status. We found high levels of apoptosis in OS cells carrying wild-type p53 gene when exposed to a-TOS, while the mutant p53 cells were resistant. A S/G2 transition arrest was observed in two OS cell lines exposed to a-TOS, which sensitised them to methotrexate, an agent whose activity is cell cycle-dependent. We propose that a-TOS ...
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    a-Tocopheryl succinate (a-TOS) exerts pleiotrophic responses in malignant cells leading to cell cycle arrest, differentiation and apoptosis. We tested the ability of a-TOS to induce apoptosis or cell cycle perturbation in three human osteosarcoma (OS) cell lines which differ in their pRB and p53 status. We found high levels of apoptosis in OS cells carrying wild-type p53 gene when exposed to a-TOS, while the mutant p53 cells were resistant. A S/G2 transition arrest was observed in two OS cell lines exposed to a-TOS, which sensitised them to methotrexate, an agent whose activity is cell cycle-dependent. We propose that a-TOS may be used as a drug or an adjuvant for treatment of osteosarcomas.
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    Journal Title
    Cancer Letters
    Volume
    232
    Issue
    2
    Publisher URI
    http://www.sciencedirect.com/science/journal/03043835
    DOI
    https://doi.org/10.1016/j.canlet.2005.02.019
    Copyright Statement
    © 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Oncology and carcinogenesis
    Cancer cell biology
    Publication URI
    http://hdl.handle.net/10072/22116
    Collection
    • Journal articles

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