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dc.contributor.authorTomasetti, M
dc.contributor.authorAndera, L
dc.contributor.authorAlleva, R
dc.contributor.authorBorghi, B
dc.contributor.authorNeuzil, J
dc.contributor.authorProcopio, A
dc.date.accessioned2017-05-03T16:55:53Z
dc.date.available2017-05-03T16:55:53Z
dc.date.issued2006
dc.date.modified2009-09-09T07:18:19Z
dc.identifier.issn0014-5793
dc.identifier.doi10.1016/j.febslet.2006.02.054
dc.identifier.urihttp://hdl.handle.net/10072/22117
dc.description.abstractWe evaluated the ability of a-tocopheryl succinate (a-TOS) to sensitise TRAIL-resistant malignant mesothelioma (MM) cells to TRAIL-induced apoptosis. We show that a-TOS activates expression of DR4/DR5 in a p53-dependent manner and re-establishes sensitivity of resistant MM cells to TRAIL-mediated apoptosis, as documented in p53wt MM cells but not in their p53null counterparts. MM cells selected for TRAIL resistance expressed low cell surface levels of DR4 and DR5. Treatment with sub-lethal doses of a-TOS restored expression of DR4 and DR5. The ability of a-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.publisher.urihttps://febs.onlinelibrary.wiley.com/doi/10.1016/j.febslet.2006.02.054
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1925
dc.relation.ispartofpageto1931
dc.relation.ispartofissue8
dc.relation.ispartofjournalFEBS Letters
dc.relation.ispartofvolume580
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchEvolutionary biology
dc.subject.fieldofresearchCancer cell biology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3104
dc.subject.fieldofresearchcode321101
dc.titleα-Tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: Implication for sensitisation of resistant cancer cells to TRAIL apoptosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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