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dc.contributor.authorLambrechts, Ruthen_US
dc.contributor.authorNeuzil, Jirien_US
dc.date.accessioned2017-04-24T14:51:47Z
dc.date.available2017-04-24T14:51:47Z
dc.date.issued2006en_US
dc.date.modified2009-09-09T07:18:08Z
dc.identifier.issn00145793en_US
dc.identifier.doi10.1016/j.febslet.2006.04.019en_AU
dc.identifier.urihttp://hdl.handle.net/10072/22118
dc.description.abstractMalignant mesothelioma (MM) is a fatal type of cancer. We studied the role of the redox-active protein thioredoxin-1 (Trx-1) in apoptosis induced in MM cells and their non-malignant counterparts (Met-5A) by a-tocopheryl succinate (a-TOS) and TNF-related apoptosis-inducing ligand (TRAIL). MM cells were susceptible to a-TOS and less to TRAIL, while Met-5A cells were susceptible to TRAIL and resistant to a-TOS. MM cells expressed very low level of the Trx-1 protein, which was high in Met-5A cells, while the level of Trx-1 mRNA was similar in all cell lines. Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to a-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier BVen_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00145793en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom2671en_US
dc.relation.ispartofpageto2676en_US
dc.relation.ispartofissue11en_US
dc.relation.ispartofjournalFEBS Lettersen_US
dc.relation.ispartofvolume580en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchCancer Cell Biologyen_US
dc.subject.fieldofresearchcode111201en_US
dc.titleRole of thioredoxin-1 in apoptosis induction by α-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2006
gro.hasfulltextNo Full Text


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