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  • Phase variable restriction-modification systems in Moraxella catarrhalis

    Author(s)
    Seib, Kate L.
    Peak, Ian R. A.
    Jennings, Michael P.
    Griffith University Author(s)
    Peak, Ian
    Year published
    2002
    Metadata
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    Abstract
    A repetitive DNA motif was used as a marker to identify novel genes in the mucosal pathogen Moraxella catarrhalis. There is a high prevalence of such repetitive motifs in virulence genes that display phase variable expression. Two repeat containing loci were identified using a digoxigenin-labelled 5P-(CAAC)6-3'P oligonucleotide probe. The repeats are located in the methylase components of two distinct type III restriction-modification (R-M) systems. We suggest that the phase variable nature of these R-M systems indicates that they have an important role in the biology of M. catarrhalis.A repetitive DNA motif was used as a marker to identify novel genes in the mucosal pathogen Moraxella catarrhalis. There is a high prevalence of such repetitive motifs in virulence genes that display phase variable expression. Two repeat containing loci were identified using a digoxigenin-labelled 5P-(CAAC)6-3'P oligonucleotide probe. The repeats are located in the methylase components of two distinct type III restriction-modification (R-M) systems. We suggest that the phase variable nature of these R-M systems indicates that they have an important role in the biology of M. catarrhalis.
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    Journal Title
    FEMS Immunology and Medical Microbiology
    Volume
    32
    Issue
    2
    DOI
    https://doi.org/10.1111/j.1574-695X.2002.tb00548.x
    Subject
    Cardiorespiratory Medicine and Haematology
    Immunology
    Medical Microbiology
    Publication URI
    http://hdl.handle.net/10072/22119
    Collection
    • Journal articles

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