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dc.contributor.authorSergeyev, A.
dc.contributor.authorPyankov, O.
dc.contributor.authorShishkina, L.
dc.contributor.authorDuben, L.
dc.contributor.authorPetrishchenko, V.
dc.contributor.authorZhukov, V.
dc.contributor.authorPyankova, O.
dc.contributor.authorSvyatchenko, L.
dc.contributor.authorSherstoboyev, E.
dc.contributor.authorKarimova, T.
dc.contributor.authorMartyushev-Poklad, A.
dc.contributor.authorSergeeva, S.
dc.contributor.authorEpstein, O.
dc.contributor.authorGlotov, A.
dc.contributor.authorGlotova, T.
dc.contributor.editorDmitrii K Lvov
dc.date.accessioned2017-05-03T16:55:47Z
dc.date.available2017-05-03T16:55:47Z
dc.date.issued2004
dc.date.modified2009-04-16T06:53:19Z
dc.identifier.issn05074088
dc.identifier.urihttp://hdl.handle.net/10072/22171
dc.description.abstractCourse intragastric administration of ultralow doses of human gamma-interferon antibodies (ULD anti-IFN-gamma) to intact mice resulted in an increase of endogenous IFN-gamma production by the animal lymphocytes. Oral prophylactic administration of ULD anti-IFN-gamma significantly lowered the influenza virus concentration in the animal lungs at the initial stage of the aerogenous infection: in 2 (p = 0.05) and 3 (p = 0.07) days after the contamination. The therapeutic antiviral effect of ULD anti-IFN-gamma in mice with influenza was evident from a significant decrease of the influenza virus concentration in the lungs of the animals on the 4th (p = 0.05) and 5th (p = 0.07) days after the contamination. The antiviral effect of ULD anti-IFN-gamma after the prophylactic and therapeutic use is likely provided by induction of endogenous IFN-gamma
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageRussian
dc.language.isorus
dc.publisherIzdatel'stvo Meditsina
dc.publisher.placeRussian Federation
dc.publisher.urihttp://www.ncbi.nlm.nih.gov/pubmed/15945542
dc.relation.ispartofpagefrom7
dc.relation.ispartofpageto11
dc.relation.ispartofissue11
dc.relation.ispartofjournalVoprosy Virusologii
dc.relation.ispartofvolume49
dc.subject.fieldofresearchcode270304
dc.titleAntiviral activity of oral ultra low doses of antibodies to gamma-interferon: experimental study of influenza infection in mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorPyankov, Oleg


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