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dc.contributor.authorDuben, L.en_US
dc.contributor.authorEpstein, O.en_US
dc.contributor.authorGlotov, A.en_US
dc.contributor.authorGlotova, T.en_US
dc.contributor.authorKarimova, T.en_US
dc.contributor.authorMartyushev-Poklad, A.en_US
dc.contributor.authorPetrishchenko, V.en_US
dc.contributor.authorPyankov, O.en_US
dc.contributor.authorPyankova, O.en_US
dc.contributor.authorSergeeva, S.en_US
dc.contributor.authorSergeyev, A.en_US
dc.contributor.authorSherstoboyev, E.en_US
dc.contributor.authorShishkina, L.en_US
dc.contributor.authorSvyatchenko, L.en_US
dc.contributor.authorZhukov, V.en_US
dc.contributor.editorDmitrii K Lvoven_US
dc.date.accessioned2017-04-05T00:16:35Z
dc.date.available2017-04-05T00:16:35Z
dc.date.issued2004en_US
dc.date.modified2009-04-16T06:53:19Z
dc.identifier.issn05074088en_US
dc.identifier.urihttp://hdl.handle.net/10072/22171
dc.description.abstractCourse intragastric administration of ultralow doses of human gamma-interferon antibodies (ULD anti-IFN-gamma) to intact mice resulted in an increase of endogenous IFN-gamma production by the animal lymphocytes. Oral prophylactic administration of ULD anti-IFN-gamma significantly lowered the influenza virus concentration in the animal lungs at the initial stage of the aerogenous infection: in 2 (p = 0.05) and 3 (p = 0.07) days after the contamination. The therapeutic antiviral effect of ULD anti-IFN-gamma in mice with influenza was evident from a significant decrease of the influenza virus concentration in the lungs of the animals on the 4th (p = 0.05) and 5th (p = 0.07) days after the contamination. The antiviral effect of ULD anti-IFN-gamma after the prophylactic and therapeutic use is likely provided by induction of endogenous IFN-gammaen_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageRussianen_US
dc.language.isoen_AU
dc.publisherIzdatel'stvo Meditsinaen_US
dc.publisher.placeRussian Federationen_US
dc.publisher.urihttp://www.ncbi.nlm.nih.gov/pubmed/15945542en_AU
dc.relation.ispartofpagefrom7en_US
dc.relation.ispartofpageto11en_US
dc.relation.ispartofissue11en_AU
dc.relation.ispartofjournalVoprosy Virusologiien_US
dc.relation.ispartofvolume49en_US
dc.subject.fieldofresearchcode270304en_US
dc.titleAntiviral activity of oral ultra low doses of antibodies to gamma-interferon: experimental study of influenza infection in miceen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2004
gro.hasfulltextNo Full Text


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