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dc.contributor.authorSilburn, PA
dc.contributor.authorMellick, GD
dc.contributor.authorVieira, BI
dc.contributor.authorDanta, G
dc.contributor.authorBoyle, RS
dc.contributor.authorHerawati, L
dc.date.accessioned2017-05-03T14:10:36Z
dc.date.available2017-05-03T14:10:36Z
dc.date.issued2008
dc.date.modified2009-04-16T06:53:44Z
dc.identifier.issn0967-5868
dc.identifier.doi10.1016/j.jocn.2007.09.018
dc.identifier.urihttp://hdl.handle.net/10072/22179
dc.description.abstractMotor and non-motor fluctuations are well known sequelae of dopaminergic therapies for Parkinson's disease (PD), particularly during the advanced stages. However, the prevalence of fluctuations early in the treatment course has been less well recognised and may be missed clinically if not specifically probed. We examined the used of a survey for this purpose. Patients to be surveyed were recruited by neurologists and geriatricians at 20 Australian centres. Patients had a diagnosis of idiopathic PD with a duration of fewer than 5 years and were considered by their treating physician to be non-fluctuating or had no change in their treatment plan in the prior 6 months. Patients, with or without assistance, completed a 19-item wearing-off questionnaire to assess the presence of motor and non-motor fluctuations that indicated early wearing-off. Investigators assessed the usefulness of the questionnaire in detecting fluctuations and guiding PD treatment. Of 105 patients recruited, 92 were eligible for analysis. There were 56 (61%) identified as having fluctuations. Patients with wearing-off were younger (mean 67 vs 72 years), and more likely to have had PD for more than 3 years. About half the patients (49%) were able to complete the questionnaire independently. Clinicians perceived the questionnaire as useful for detecting fluctuations and adjusting treatment. A simple and easily administered wearing-off questionnaire may be useful in the early detection of fluctuations in PD patients and assist in guiding therapy.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://www.elsevier.com/locate/jocn
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1235
dc.relation.ispartofpageto1239
dc.relation.ispartofissue11
dc.relation.ispartofjournalJournal of Clinical Neuroscience
dc.relation.ispartofvolume15
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.titleUtility of a patient survey in identifying fluctuations in early stage Parkinson’s disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2008 Elsevier. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George


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