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dc.contributor.authorSergeev, A.en_US
dc.contributor.authorShishkina, L.en_US
dc.contributor.authorZhukov, V.en_US
dc.contributor.authorSergeev, A.en_US
dc.contributor.authorPetrishchenko, V.en_US
dc.contributor.authorFankin, I.en_US
dc.contributor.authorPyankov, O.en_US
dc.contributor.authorRyabchikova, E.en_US
dc.contributor.authorMalkova, E.en_US
dc.contributor.authorVorobyov, A.en_US
dc.contributor.editorNikolai P Bochkoven_US
dc.description.abstractThe purpose of the case study was to evaluate comparatively the relative contribution of cell susceptibility and the inhibiting effect of factors of pulmonary epithelial lining in mice and rats to influenza virus A/Aichi/2/68 (H3N2) adapted to mice as related with the development of infection process in the lungs of experimental animals when infected in vivo and in vitro. Mice and rats were infected aerogenically with different doses of influenza virus. The primary cell-culture suspensions sampled from the lungs of mice and rats were used to study the adsorption and dynamics of influenza virus production in infection by different dose of influenza virus in vitro. The cell suspensions were shown to be able to produce the influenza virus for as long as 48 hours after infection. It was for the first time that the results denoted the identical susceptibility of primary pulmonary cells in mice and rats to influenza virus. A lower pulmonary susceptibility to influenza virus in rats versus mice could be indicative of that the surface factors of epithelial lining contribute essentially to shaping the pulmonary susceptibility to influenza virus since there is no difference of the susceptibility of pulmonary cells to influenza virus between the two above animals' species.en_US
dc.publisherIzdatel'stvo Meditsinaen_US
dc.publisher.placeRussian Federationen_US
dc.relation.ispartofjournalRossiiskaya Akademiya Meditsinskikh Nauk. Vestniken_US
dc.titlePulmonary cell susceptibility in mice and rats to influenza virus when infected in vivo and in vitroen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text

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