Show simple item record

dc.contributor.authorHofmann, A
dc.contributor.authorHess, S
dc.contributor.authorNoegel, AA
dc.contributor.authorSchleicher, M
dc.contributor.authorWlodawer, A
dc.date.accessioned2017-05-03T15:19:18Z
dc.date.available2017-05-03T15:19:18Z
dc.date.issued2002
dc.date.modified2009-04-17T05:28:14Z
dc.identifier.issn2059-7983
dc.identifier.doi10.1107/S0907444902013306
dc.identifier.urihttp://hdl.handle.net/10072/22209
dc.description.abstractCyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which binds to the cyclase in a different region. With its other domain, CAP can bind monomeric actin and therefore also carries a cytoskeletal function. The protein is thus involved in Ras/cAMP-dependent signal transduction and most likely serves as an adapter protein translocating the adenylyl cyclase complex to the actin cytoskeleton. Crystals belonging to the orthorhombic space group C222, with unitcell parameters a = 71.2, b = 75.1, c = 162.9 A ʠ, have been obtained from Dictyostelium discoideum CAP carrying a C-terminal His tag. A complete native data set extending to 2.2 A ʠresolution was collected from a single crystal using an in-house X-ray system. The asymmetric unit contains one molecule of CAP.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell Munksgaard
dc.publisher.placeCopenhagen, Denmark
dc.relation.ispartofpagefrom1858
dc.relation.ispartofpageto1861
dc.relation.ispartofissue10
dc.relation.ispartofjournalActa crystallographica. Section D, Biological crystallography
dc.relation.ispartofvolumeD58
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchPhysical Sciences
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode02
dc.titleCrystallization of cyclase-associated protein from Dictyostelium discoideum
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2002
gro.hasfulltextNo Full Text
gro.griffith.authorHofmann, Andreas


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record