Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei

Abstract

Chem. investigation of the Philippine ascidian Perophora namei has resulted in the isolation of a novel polycyclic alkaloid, perophoramidine (I). The structure of I was detd. by the interpretation of 1D/2D NMR and MS data. Dehalogenation of perophoramidine by ammonium formate catalyzed transfer hydrogenation confirmed the type and no. of halogen atoms present in I.