Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.

Sandoval, IT; Davis, RA; Bugni, TS; Concepcion, GP; Harper, MK; Ireland, CM

doi:10.1080/1057563031000122130

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Author(s)

Sandoval, IT

Davis, RA

Bugni, TS

Concepcion, GP

Harper, MK

Ireland, CM

Griffith University Author(s)

Davis, Rohan A.

Year published

2004

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Abstract

Bioassay-guided fractionation of two Philippine sponges of the genus Petrosia has resulted in the isolation of the novel natural product cribrostatin 7 (I) and the known compds. renierone (II) and O-demethylrenierone (III). The structures of these isoquinoline quinones were detd. by interpretation of spectroscopic data. Compds. I, II and III were cytotoxic against the HCT 116 human colon carcinoma cell line with IC50 values of 45, 24 and 34 mg/mL, resp.Bioassay-guided fractionation of two Philippine sponges of the genus Petrosia has resulted in the isolation of the novel natural product cribrostatin 7 (I) and the known compds. renierone (II) and O-demethylrenierone (III). The structures of these isoquinoline quinones were detd. by interpretation of spectroscopic data. Compds. I, II and III were cytotoxic against the HCT 116 human colon carcinoma cell line with IC50 values of 45, 24 and 34 mg/mL, resp.
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Journal Title

Natural Product Research

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Issue

Publisher URI

http://www.tandf.co.uk/journals/titles/14786419.asp

DOI

https://doi.org/10.1080/1057563031000122130

Copyright Statement

© 2004 Taylor & Francis. Please refer to the journal's website for access to the definitive, published version. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.

Publication URI

http://hdl.handle.net/10072/22219

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Journal articles