Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.

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Author(s)
Sandoval, IT
Davis, RA
Bugni, TS
Concepcion, GP
Harper, MK
Ireland, CM
Griffith University Author(s)
Year published
2004
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Show full item recordAbstract
Bioassay-guided fractionation of two Philippine sponges of the genus Petrosia has resulted in the isolation of the novel natural product cribrostatin 7 (I) and the known compds. renierone (II) and O-demethylrenierone (III). The structures of these isoquinoline quinones were detd. by interpretation of spectroscopic data. Compds. I, II and III were cytotoxic against the HCT 116 human colon carcinoma cell line with IC50 values of 45, 24 and 34 mg/mL, resp.Bioassay-guided fractionation of two Philippine sponges of the genus Petrosia has resulted in the isolation of the novel natural product cribrostatin 7 (I) and the known compds. renierone (II) and O-demethylrenierone (III). The structures of these isoquinoline quinones were detd. by interpretation of spectroscopic data. Compds. I, II and III were cytotoxic against the HCT 116 human colon carcinoma cell line with IC50 values of 45, 24 and 34 mg/mL, resp.
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Journal Title
Natural Product Research
Volume
18
Issue
1
Publisher URI
Copyright Statement
© 2004 Taylor & Francis. Please refer to the journal's website for access to the definitive, published version. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.