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dc.contributor.authorDavis, Rohan A.
dc.contributor.authorMangalindan, Gina C.
dc.contributor.authorBojo, Zenaida P.
dc.contributor.authorAntemano, Rowena R.
dc.contributor.authorRodriguez, Nell O.
dc.contributor.authorConcepcion, Gisela P.
dc.contributor.authorSamson, Shiela C.
dc.contributor.authorGuzman, Dennis
dc.contributor.authorCruz, Lourdes J.
dc.contributor.authorTasdemir, Deniz
dc.contributor.authorHarper, Mary Kay
dc.contributor.authorFeng, Xidong
dc.contributor.authorCarter, Guy T.
dc.contributor.authorIreland, Chris M.
dc.date.accessioned2017-05-03T12:46:36Z
dc.date.available2017-05-03T12:46:36Z
dc.date.issued2004
dc.date.modified2009-08-21T06:38:05Z
dc.identifier.issn00223263
dc.identifier.doi10.1002/chin.200444211
dc.identifier.urihttp://hdl.handle.net/10072/22220
dc.description.abstractMicrocionamides A (1) and B (2) have been isolated from the Philippine marine sponge Clathria (Thalysias) abietina. These new linear peptides are cyclized via a cystine moiety and have their C-terminus blocked by a 2-phenylethylenamine group. Their total structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Compound 1 was shown to slowly isomerize about the C-36/C-37 double bond when stored in DMSO. Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherThe American Chemical Society
dc.publisher.placeWashington, D.C.
dc.publisher.urihttp://pubs.acs.org/journal/joceah
dc.relation.ispartofpagefrom4170
dc.relation.ispartofpageto4176
dc.relation.ispartofjournalJournal of Organic Chemistry
dc.relation.ispartofvolume69
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.titleMicrocionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2004 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher.
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorDavis, Rohan A.


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