dc.contributor.author | Davis, Rohan A. | |
dc.contributor.author | Mangalindan, Gina C. | |
dc.contributor.author | Bojo, Zenaida P. | |
dc.contributor.author | Antemano, Rowena R. | |
dc.contributor.author | Rodriguez, Nell O. | |
dc.contributor.author | Concepcion, Gisela P. | |
dc.contributor.author | Samson, Shiela C. | |
dc.contributor.author | Guzman, Dennis | |
dc.contributor.author | Cruz, Lourdes J. | |
dc.contributor.author | Tasdemir, Deniz | |
dc.contributor.author | Harper, Mary Kay | |
dc.contributor.author | Feng, Xidong | |
dc.contributor.author | Carter, Guy T. | |
dc.contributor.author | Ireland, Chris M. | |
dc.date.accessioned | 2017-05-03T12:46:36Z | |
dc.date.available | 2017-05-03T12:46:36Z | |
dc.date.issued | 2004 | |
dc.date.modified | 2009-08-21T06:38:05Z | |
dc.identifier.issn | 00223263 | |
dc.identifier.doi | 10.1002/chin.200444211 | |
dc.identifier.uri | http://hdl.handle.net/10072/22220 | |
dc.description.abstract | Microcionamides A (1) and B (2) have been isolated from the Philippine marine sponge Clathria (Thalysias) abietina. These new linear peptides are cyclized via a cystine moiety and have their C-terminus blocked by a 2-phenylethylenamine group. Their total structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Compound 1 was shown to slowly isomerize about the C-36/C-37 double bond when stored in DMSO. Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | The American Chemical Society | |
dc.publisher.place | Washington, D.C. | |
dc.publisher.uri | http://pubs.acs.org/journal/joceah | |
dc.relation.ispartofpagefrom | 4170 | |
dc.relation.ispartofpageto | 4176 | |
dc.relation.ispartofjournal | Journal of Organic Chemistry | |
dc.relation.ispartofvolume | 69 | |
dc.subject.fieldofresearch | Medicinal and Biomolecular Chemistry | |
dc.subject.fieldofresearch | Organic Chemistry | |
dc.subject.fieldofresearchcode | 0304 | |
dc.subject.fieldofresearchcode | 0305 | |
dc.title | Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2004 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. | |
gro.date.issued | 2004 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Davis, Rohan A. | |