Rational design of potent sialidase-based inhibitors of influenza virus replication
Author(s)
VONITZSTEIN, M
WU, WY
KOK, GB
PEGG, MS
DYASON, JC
JIN, B
PHAN, TV
SMYTHE, ML
WHITE, HF
OLIVER, SW
COLMAN, PM
VARGHESE, JN
RYAN, DM
WOODS, JM
BETHELL, RC
HOTHAM, VJ
CAMERON, JM
PENN, CR
Griffith University Author(s)
Year published
1993
Metadata
Show full item recordAbstract
Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.
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Journal Title
Nature: International weekly journal of science
Volume
363
Issue
6428
Subject
Biochemistry and cell biology not elsewhere classified