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dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.authorWu, Wen-Yangen_US
dc.contributor.authorB. Kok, Gaiken_US
dc.contributor.authorS. Pegg, Michaelen_US
dc.contributor.authorC. Dyason, Jeffreyen_US
dc.contributor.authorJin, Bettyen_US
dc.contributor.authorVan Phan, Thoen_US
dc.contributor.authorL. Smythe, Marken_US
dc.contributor.authorF. White, Humeen_US
dc.contributor.authorW. Oliver, Stuarten_US
dc.contributor.authorM. Colman, Peteren_US
dc.contributor.authorN. Varghese, Josephen_US
dc.contributor.authorMichael Ryan, D.en_US
dc.contributor.authorM. Woods, Jacquelineen_US
dc.contributor.authorC. Bethell, Richarden_US
dc.contributor.authorJ. Hotham, Vanessaen_US
dc.contributor.authorM. Cameron, Janeten_US
dc.contributor.authorR. Penn, Charlesen_US
dc.date.accessioned2017-04-24T14:51:20Z
dc.date.available2017-04-24T14:51:20Z
dc.date.issued1993en_US
dc.date.modified2009-04-17T05:30:47Z
dc.identifier.issn00280836en_US
dc.identifier.doi10.1038/363418a0en_AU
dc.identifier.urihttp://hdl.handle.net/10072/22238
dc.description.abstractTwo potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherNature Publishing Groupen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofpagefrom418en_US
dc.relation.ispartofpageto423en_US
dc.relation.ispartofissue6428en_US
dc.relation.ispartofjournalNature: International weekly journal of scienceen_US
dc.relation.ispartofvolume363en_US
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060199en_US
dc.titleRational design of potent sialidase-based inhibitors of influenza virus replicationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued1993
gro.hasfulltextNo Full Text


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