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dc.contributor.authorRastan, Sohailaen_US
dc.contributor.authorHough, Tertiusen_US
dc.contributor.authorKierman, Amyen_US
dc.contributor.authorHardisty, Rachelen_US
dc.contributor.authorErven, Alexandraen_US
dc.contributor.authorC. Gray, Ianen_US
dc.contributor.authorVoeling, Stepanieen_US
dc.contributor.authorIsaacs, Adrianen_US
dc.contributor.authorTsai, Hsunen_US
dc.contributor.authorStrivens, Marken_US
dc.contributor.authorWashbourne, Rebeccaen_US
dc.contributor.authorThornton, Claireen_US
dc.contributor.authorGreenaway, Simonen_US
dc.contributor.authorHewitt, Mazdaen_US
dc.contributor.authorMcCormick, Stefanen_US
dc.contributor.authorSelley, Rachaelen_US
dc.contributor.authorWells, Christineen_US
dc.contributor.authorTymowska-Lalanne, Zuzannaen_US
dc.contributor.authorRoby, Philen_US
dc.contributor.authorMburu, Philomenaen_US
dc.contributor.authorRogers, Dereken_US
dc.contributor.authorHagan, Jimen_US
dc.contributor.authorReavill, Charlieen_US
dc.contributor.authorDavies, Kayen_US
dc.contributor.authorGlenister, Peteren_US
dc.contributor.authoral, eten_US
dc.description.abstractWith the completion of the first draft of the human genome sequence, the next major challenge is assigning function to genes. One approach is genome-wide random chemical mutagenesis, followed by screening for mutant phenotypes of interest and subsequent mapping and identification of the mutated genes in question. We (a consortium made up of GlaxoSmithKline, the MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, Imperial College, London, and the Royal London Hospital) have used ENU mutagenesis in the mouse for the rapid generation of novel mutant phenotypes for use as animal models of human disease and for gene function assignment (Nolan et al., 2000). As of 2003, 35,000 mice have been produced to date in a genome-wide screen for dominant mutations and screened using a variety of screening protocols. Nearly 200 mutants have been confirmed as heritable and added to the mouse mutant catalogue and, overall, we can extrapolate that we have recovered over 700 mutants from the screening programme.en_US
dc.publisherKluwer Academic Publishersen_US
dc.subject.fieldofresearchGenetics not elsewhere classifieden_US
dc.titleTowards a mutant map of the mouse – new models of neurological, behavioural, deafness, bone, renal and blood disordersen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text

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