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  • A study of possibility to predict the sensitivity of different respiratory tract divisions to influenza

    Author(s)
    Zhukov, V.
    Shishkina, L.
    Sergeyev, A.
    Fankin, I.
    Smetannikova, M.
    Pyankov, O.
    Petrischenko, V.
    Sergeyev, A.
    Vorobyov, A.
    Griffith University Author(s)
    Pyankov, Oleg
    Year published
    2007
    Metadata
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    Abstract
    To predict a potential value of a viral ID50 for a macro-organism of interest (e.g. humans), it is necessary to determine in vitro two parameters of the interaction of the virus with susceptible cells of the host, i.e. the probability of the virus' productive absorption on a susceptible cell and the average virus yield per cell. A different macroorganism (a model animal) and primary cells obtained from it can be used to determine the value of a scale factor, which accounts for the difference between the values of the probability of the virus' absorption measured in vivo and in vitro. An original mathematical model is used ...
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    To predict a potential value of a viral ID50 for a macro-organism of interest (e.g. humans), it is necessary to determine in vitro two parameters of the interaction of the virus with susceptible cells of the host, i.e. the probability of the virus' productive absorption on a susceptible cell and the average virus yield per cell. A different macroorganism (a model animal) and primary cells obtained from it can be used to determine the value of a scale factor, which accounts for the difference between the values of the probability of the virus' absorption measured in vivo and in vitro. An original mathematical model is used to convert the above-mentioned data to ID50 for the macroorganism of interest. It was shown that the method of cultivating influenza virus (A/ Aichi/2/68) in primary suspension culture of respiratory tract cells of rats and two breeds of mice may be used to estimate potential human susceptibility to novel influenza viruses. This work was sponsored by DAPRA, USA, and performed under the contract 450p to the International Science and Technology Center, Moscow.
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    Journal Title
    Rossiiskaya Akademiya Meditsinskikh Nauk. Vestnik
    Volume
    2007
    Issue
    5
    Publisher URI
    http://www.ncbi.nlm.nih.gov/pubmed/17601039
    Publication URI
    http://hdl.handle.net/10072/22243
    Collection
    • Journal articles

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