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dc.contributor.authorZhukov, V.en_US
dc.contributor.authorShishkina, L.en_US
dc.contributor.authorSergeyev, A.en_US
dc.contributor.authorFankin, I.en_US
dc.contributor.authorSmetannikova, M.en_US
dc.contributor.authorPyankov, O.en_US
dc.contributor.authorPetrischenko, V.en_US
dc.contributor.authorSergeyev, A.en_US
dc.contributor.authorVorobyov, A.en_US
dc.contributor.editorNikolai P Bochkoven_US
dc.date.accessioned2017-05-03T16:56:00Z
dc.date.available2017-05-03T16:56:00Z
dc.date.issued2007en_US
dc.date.modified2009-04-17T05:31:00Z
dc.identifier.issn08696047en_US
dc.identifier.urihttp://hdl.handle.net/10072/22243
dc.description.abstractTo predict a potential value of a viral ID50 for a macro-organism of interest (e.g. humans), it is necessary to determine in vitro two parameters of the interaction of the virus with susceptible cells of the host, i.e. the probability of the virus' productive absorption on a susceptible cell and the average virus yield per cell. A different macroorganism (a model animal) and primary cells obtained from it can be used to determine the value of a scale factor, which accounts for the difference between the values of the probability of the virus' absorption measured in vivo and in vitro. An original mathematical model is used to convert the above-mentioned data to ID50 for the macroorganism of interest. It was shown that the method of cultivating influenza virus (A/ Aichi/2/68) in primary suspension culture of respiratory tract cells of rats and two breeds of mice may be used to estimate potential human susceptibility to novel influenza viruses. This work was sponsored by DAPRA, USA, and performed under the contract 450p to the International Science and Technology Center, Moscow.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageRussianen_US
dc.language.isoen_AU
dc.publisherIzdatel'stvo Meditsinaen_US
dc.publisher.placeRussian Federationen_US
dc.publisher.urihttp://www.ncbi.nlm.nih.gov/pubmed/17601039en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom32en_US
dc.relation.ispartofpageto37en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalRossiiskaya Akademiya Meditsinskikh Nauk. Vestniken_US
dc.relation.ispartofvolume2007en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270304en_US
dc.titleA study of possibility to predict the sensitivity of different respiratory tract divisions to influenzaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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