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  • Antigens for cancer immunotherapy

    Author
    A. Neller, Michelle
    Lopez, Alejandro
    W. Schmidt, Christopher
    Year published
    2008
    Metadata
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    Abstract
    Progress in tumor immunology has not been translated to effective immunotherapies for cancer. Most of the current effort in basic and clinical research concentrates on generating effective immune responses against model or well characterized antigens, yet vaccines targeting defined antigens have been less clinically successful than those based on whole tumor cells or their extracts. This review considers characteristics of proteins that determine how effectively they might serve as targets of immune control, and how different sources of antigens have fared in clinical trials.Progress in tumor immunology has not been translated to effective immunotherapies for cancer. Most of the current effort in basic and clinical research concentrates on generating effective immune responses against model or well characterized antigens, yet vaccines targeting defined antigens have been less clinically successful than those based on whole tumor cells or their extracts. This review considers characteristics of proteins that determine how effectively they might serve as targets of immune control, and how different sources of antigens have fared in clinical trials.
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    Journal Title
    Seminars in Immunology
    Volume
    20
    Publisher URI
    http://www.sciencedirect.com/science/journal/10445323
    DOI
    https://doi.org/10.1016/j.smim.2008.09.006
    Publication URI
    http://hdl.handle.net/10072/22378
    Collection
    • Journal articles

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