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dc.contributor.authorMurrell, Wayne
dc.contributor.authorWetzig, Andrew
dc.contributor.authorDonnellan, Michael
dc.contributor.authorFeron, Francois
dc.contributor.authorBurne, Tom
dc.contributor.authorMeedeniya, Adrian
dc.contributor.authorKesby, James
dc.contributor.authorBianco, John
dc.contributor.authorPerry, Chris
dc.contributor.authorSilburn, Peter
dc.contributor.authorMackay-Sim, Alan
dc.contributor.editorCurt I. Civin
dc.date.accessioned2017-05-03T15:24:49Z
dc.date.available2017-05-03T15:24:49Z
dc.date.issued2008
dc.date.modified2009-09-21T05:49:35Z
dc.identifier.issn1066-5099
dc.identifier.doi10.1634/stemcells.2008-0074
dc.identifier.urihttp://hdl.handle.net/10072/22512
dc.description.abstractParkinson's disease is a complex disorder characterized by degeneration of dopaminergic neurons in the substantia nigra in the brain. Stem cell transplantation is aimed at replacing dopaminergic neurons because the most successful drug therapies affect these neurons and their synaptic targets. We show here that neural progenitors can be grown from the olfactory organ of humans, including those with Parkinson's disease. These neural progenitors proliferated and generated dopaminergic cells in vitro. They also generated dopaminergic cells when transplanted into the brain and reduced the behavioral asymmetry induced by ablation of the dopaminergic neurons in the rat model of Parkinson's disease. Our results indicate that Parkinson's patients could provide their own source of neuronal progenitors for cell transplantation therapies and for direct investigation of the biology and treatments of Parkinson's disease. Disclosure of potential conflicts of interest is found at the end of this article.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAlphaMed Press, Inc.
dc.publisher.placeUnited States
dc.publisher.urihttp://www.stemcells.com/view/0/index.html
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2183
dc.relation.ispartofpageto2192
dc.relation.ispartofeditionJune 5, 2008
dc.relation.ispartofissue8
dc.relation.ispartofjournalStem Cells: the international journal of cell differentiation and proliferation
dc.relation.ispartofvolume26
dc.rights.retentionN
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode10
dc.subject.fieldofresearchcode11
dc.titleOlfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2008 AlphaMed Press. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information.
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan
gro.griffith.authorMurrell, Wayne G.
gro.griffith.authorSilburn, Peter A.
gro.griffith.authorBianco, John I.
gro.griffith.authorWetzig, Andrew R.
gro.griffith.authorDonnellan, Michael
gro.griffith.authorBurne, Thomas HJ.
gro.griffith.authorMeedeniya, Adrian C.
gro.griffith.authorFeron, Francois


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