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dc.contributor.authorDoi, Kojien_US
dc.contributor.authorFukada, Yasuyoen_US
dc.contributor.authorHata, Yoshioen_US
dc.contributor.authorIshimoto, Mihoen_US
dc.contributor.authorKarunaratne, Asankaen_US
dc.contributor.authorKitayama, Michioen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.contributor.authorMorita, Erien_US
dc.contributor.authorMurrell, Wayneen_US
dc.contributor.authorNakano, Toshiyaen_US
dc.contributor.authorNakashima, Kenjien_US
dc.contributor.authorSutharsan, Ratneswaryen_US
dc.contributor.authorWatanabe, Yauhiroen_US
dc.contributor.authorYasui, Kenichien_US
dc.contributor.editorS Gilman (Editor-in-Chief)en_US
dc.date.accessioned2017-04-04T21:37:23Z
dc.date.available2017-04-04T21:37:23Z
dc.date.issued2008en_US
dc.date.modified2009-09-22T05:51:20Z
dc.identifier.issn00144886en_US
dc.identifier.doi10.1016/j.expneurol.2008.07.011en_AU
dc.identifier.urihttp://hdl.handle.net/10072/22515
dc.description.abstractAmyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease, which selectively affects motor neurons throughout the central nervous system. The extensive distribution of motor neurons is an obstacle to applying cell transplantation therapy for the treatment of ALS. To overcome this problem, we developed a cell transplantation method via the fourth cerebral ventricle in mice. We used mouse olfactory ensheathing cells (OECs) and rat mesenchymal stem cells (MSCs) as donor cells. OECs are reported to promote regeneration and remyelination in the spinal cord, while MSCs have a capability to differentiate into several types of specific cells including neural cells. Furthermore both types of cells can be relatively easily obtained by biopsy in human. Initially, we confirmed the safety of the operative procedure and broad distribution of grafted cells in the spinal cord using wild-type mice. After transplantation, OECs distributed widely and survived as long as 100 days after transplantation, with a time-dependent depletion of cell number. In ALS model mice, OEC transplantation revealed no adverse effects but no significant differences in clinical evaluation were found between OEC-treated and non-transplanted animals. After MSC transplantation into the ALS model mice, females, but not males, showed a statistically longer disease duration than the non-transplanted controls. We conclude that intrathecal ansplantation could be a promising way to deliver donor cells to the central nervous system. Further experiments to elucidate relevant conditions for optimal outcomes are required.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAcademic Press / Elsevieren_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00144886en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom431en_US
dc.relation.ispartofpageto438en_US
dc.relation.ispartofissue2en_AU
dc.relation.ispartofjournalExperimental Neurologyen_US
dc.relation.ispartofvolume213en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode320705en_US
dc.subject.fieldofresearchcode321013en_US
dc.titleA novel cell transplantation protocol and its application to an ALS mouse modelen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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