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  • Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease.

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    Author(s)
    Chapuis, Julien
    Moisan, Frederic
    Mellick, Georges
    Elbaz, Alexis
    Silburn, Peter
    Pasquier, Florence
    Hannequin, Didier
    Lendon, Corinne
    Campion, Dominique
    Amouyel, Philippe
    Lambert, Jean-Charles
    Griffith University Author(s)
    Silburn, Peter A.
    Mellick, George
    Year published
    2008
    Metadata
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    Abstract
    Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD case-control studies (n = 3176) and two independent PD case-control studies (n = 1855). However, we failed to detect an association of this SNP with the risk of ...
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    Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD case-control studies (n = 3176) and two independent PD case-control studies (n = 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.
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    Journal Title
    Human Molecular Genetics
    Volume
    17
    Issue
    18
    DOI
    https://doi.org/10.1093/hmg/ddn183
    Copyright Statement
    © 2008 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Molecular Genetics following peer review. The definitive publisher-authenticated version Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease, Human Molecular Genetics, Vol. 17(18), 2008, pp. 2863-2867 is available online at: http://dx.doi.org/10.1093/hmg/ddn183.
    Subject
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/22558
    Collection
    • Journal articles

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