Aplysamine 6, an Alkaloidal Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase from the Sponge Pseudoceratina sp.

Buchanan, Malcolm S; Carroll, Anthony R; Fechner, Gregory A; Boyle, Anthony; Simpson, Moana; Addepalli, Rama; Avery, Vicky M; Hooper, John NA; Cheung, Tony; Chen, Huwei; Quinn, Ronald J

doi:10.1021/np0706623

Author(s)

Buchanan, Malcolm S

Carroll, Anthony R

Fechner, Gregory A

Boyle, Anthony

Simpson, Moana

Addepalli, Rama

Avery, Vicky M

Hooper, John NA

Cheung, Tony

Chen, Huwei

Quinn, Ronald J

Griffith University Author(s)

Quinn, Ronald J.

Carroll, Anthony R.

Avery, Vicky M.

Year published

2008

Metadata

Show full item record

Abstract

The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an a,߭unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an a,߭unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.
View less >

Journal Title

Journal of Natural Products

Volume

Issue

Publisher URI

http://pubs.acs.org/journal/jnprdf

DOI

https://doi.org/10.1021/np0706623

Copyright Statement

© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.

Subject

Chemical sciences

Biological sciences

Biomedical and clinical sciences

Publication URI

http://hdl.handle.net/10072/22569

Collection

Journal articles