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  • Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa

    Author(s)
    Buchanan, Malcolm S
    Carroll, Anthony R
    Wessling, Deborah
    Jobling, Michael
    Avery, Vicky M
    Davis, Rohan A
    Feng, Yunjiang
    Xue, Yafeng
    Oster, Linda
    Fex, Tomas
    Deinum, Johanna
    Hooper, John NA
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Davis, Rohan A.
    Carroll, Anthony R.
    Avery, Vicky M.
    Feng, Yun J.
    Year published
    2008
    Metadata
    Show full item record
    Abstract
    Bioassay-guided fractionation of a CH2Cl2/MeOH extract of the sponge Suberea claVata using the serine protease factor XIa to detect antithrombotic activity led to the isolation of the new marine natural products, clavatadines A and B. Clavatadines A and B inhibited factor XIa with IC50's of 1.3 and 27 卬 respectively. A crystal structure of protein-inhibitor (clavatadine A) complex was obtained and revealed interesting selective binding and irreversible inhibition of factor XIa. The cocrystal structure provides guidance for the design and synthesis of future factor XIa inhibitors as antithrombotic agents.Bioassay-guided fractionation of a CH2Cl2/MeOH extract of the sponge Suberea claVata using the serine protease factor XIa to detect antithrombotic activity led to the isolation of the new marine natural products, clavatadines A and B. Clavatadines A and B inhibited factor XIa with IC50's of 1.3 and 27 卬 respectively. A crystal structure of protein-inhibitor (clavatadine A) complex was obtained and revealed interesting selective binding and irreversible inhibition of factor XIa. The cocrystal structure provides guidance for the design and synthesis of future factor XIa inhibitors as antithrombotic agents.
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    Journal Title
    Journal of Medicinal Chemistry
    Volume
    51
    Issue
    12
    Publisher URI
    http://pubs.acs.org/journal/jmcmar
    Copyright Statement
    © 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/22570
    Collection
    • Journal articles

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