Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala

Author(s)
Davis, Rohan A
Simpson, Moana M
Nugent, Ryan B
Carroll, Anthony R
Avery, Vicky M
Rali, Topul
Chen, Huawei
Qurallo, Barbara
Quinn, Ronald J
Griffith University Author(s)
Year published
2008
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Abstract
Bioassay-guided fractionation of an organic extract from the leaves of Cupaniopsis macropetala resulted in the isolation of a new alkaloid, galloyl tyramine (1), together with the known flavonoid glycoside quercitrin (2). The structure of 1 was determined following 1D and 2D NMR, IR, UV, and MS data analysis. Compounds 1 and 2 displayed IC50 values of 161 and 25 卬 respectively, in a Pim2 enzyme assay.
Journal Title
Journal of Natural Products
Volume
71
Issue
3
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Copyright Statement
© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
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