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dc.contributor.authorGao, Jinen_US
dc.contributor.authorL. Collard, Rachaelen_US
dc.contributor.authorBui, Loanen_US
dc.contributor.authorC. Herington, Adrianen_US
dc.contributor.authorNicol, David L.en_US
dc.contributor.authorA. Clements, Judithen_US
dc.date.accessioned2017-05-03T14:31:48Z
dc.date.available2017-05-03T14:31:48Z
dc.date.issued2007en_US
dc.date.modified2009-04-20T04:46:42Z
dc.identifier.issn0270-4137en_US
dc.identifier.doi10.1002/pros.20465en_AU
dc.identifier.urihttp://hdl.handle.net/10072/22606
dc.description.abstractBACKGROUND. Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS. Immunohistochemistry, in vitro co-culture, cell migration, and attachment assays. RESULTS. hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co-cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co-culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4-transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone-matrix proteins, collagens I and IV. CONCLUSIONS. hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Liss,Inc.en_US
dc.publisher.placeUSAen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom348en_US
dc.relation.ispartofpageto360en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalThe Prostateen_US
dc.relation.ispartofvolume67en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250302en_US
dc.subject.fieldofresearchcode270105en_US
dc.subject.fieldofresearchcode320202en_US
dc.titleKallikrein 4 Is a Potential Mediator of Cellular Interactions Between Cancer Cells and Osteoblasts in Metastatic Prostate Canceren_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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