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dc.contributor.authorLiu, Xiangen_US
dc.contributor.authorD. Banister, Samuelen_US
dc.contributor.authorJ. Christie, MacDonalden_US
dc.contributor.authorBanati, Richarden_US
dc.contributor.authorMeikle, Steveen_US
dc.contributor.authorJ. Coster, Marken_US
dc.contributor.authorKassiou, Michaelen_US
dc.date.accessioned2017-05-03T15:16:47Z
dc.date.available2017-05-03T15:16:47Z
dc.date.issued2007en_US
dc.date.modified2009-04-20T04:47:18Z
dc.identifier.issn00142999en_US
dc.identifier.doi10.1016/j.ejphar.2006.10.020en_AU
dc.identifier.urihttp://hdl.handle.net/10072/22620
dc.description.abstractTrishomocubane analogs TC1 (I) and TC4 (II) were evaluated for their modulatory effects on locomotor activity as well as interactions with cocaine-induced responses. TC1 and TC4 have high affinity and moderate to high selectivity for s1 (Ki = 10 nM, s1/s2 = 0.03) and s2 (Ki = 20 nM, s1/s2 = 7.6) receptor subtypes resp. Both compds. have negligible affinity for the dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters. In behavioral studies, TC1 produced a dose-related inhibition in spontaneous locomotor activity measured in a Digiscan app. TC1 attenuated the stimulatory locomotor effect of 20 mg/kg cocaine with a half-maximal depressant activity (ID50) of 38.6 mg/kg. TC1 (dose range of 25 to 100 mg/kg) also partially substituted for the effect of cocaine (10 mg/kg) in a discriminative stimulus task, involving the trained discrimination between cocaine and saline using a two-lever choice method. Following a dose of 50 mg/kg TC1, a max. of 31% substitution was reached. The response rate was reduced to 56% of vehicle control following a TC1 dose of 100 mg/kg. These behavioral effects suggest that TC1 can act as an antagonist via the s1 receptor. In contrast to TC1, TC4 produced a stimulant effect in locomotor activity with the ED50 estd. at 0.94 mg/kg. In addn., TC4 failed to inhibit cocaine-induced stimulation; neither did it substitute for the discriminative stimulus effects of cocaine. TC4 thus appears to interact predominantly with the s2 receptor subtype (s1/s2 = 7.6) which may result in dopamine stimulation independent of the effects of cocaine. The differential effect of TC1 and TC4 warrants further study of the mechanism of these actions. Present data also suggests a potential role for trishomocubane analogs in developing medication or research tools for cocaine addiction.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier B.V.en_US
dc.publisher.placeNew Yorken_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00142999en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom37en_US
dc.relation.ispartofpageto42en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalEuropean Journal of Pharmacologyen_US
dc.relation.ispartofvolume555en_US
dc.rights.retentionNen_AU
dc.subject.fieldofresearchcode250302en_US
dc.subject.fieldofresearchcode300512en_US
dc.titleTrishomocubanes: Novel σ ligands modulate cocaine-induced behavioural effectsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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