Exercise-related change in airway blood flow in humans: relationship to changes in cardiac output and ventilation
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This study examined the relationship between airway blood flow ( .Q aw), ventilation ( .V E) and cardiac output ( .Q tot) during exercise in healthy humans (n = 12, mean age 34?11 yr). .Q aw was estimated from the uptake of the soluble gas dimethyl ether while .V E and .Q tot were measured using open circuit spirometry. Measurements were made prior to and during exercise at 34?5 W (Load 1) and 68?10 W (Load 2) and following the cessation of exercise (recovery). .Q aw increased in a stepwise fashion (P<0.05) from rest (52.8 ? 19.5 ul?min-1?ml-1) to exercise at Load 1 (67.0 ? 20.3 ul?min-1?ml-1) and Load 2 (84.0 ? 22.9 ul?min-1?ml-1) before returning to pre-exercise levels in recovery (51.7 ? 13.2 ul?min-1?ml-1). .Q aw was positively correlated with both .Q tot (r=0.58, P<0.01) and .V E (r=0.50, P<0.01). These results demonstrate that the increase in .Q aw is linked to an exercise related increase in both .Q tot and .V E and may be necessary to prevent excessive airway cooling and drying
Respiratory Physiology & Neurobiology
Copyright 2008 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.