A chemoenzymatic synthesis of the styryllactone (+)-goniodiol from naphthalene.
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The enantiomerically pure cis-1,2-diol I, which is obtained by microbial oxidn. of naphthalene, has been converted, via a sequence of reactions including oxidative C-C bond cleavage, decarbonylation and ring-closing metathesis steps, into the natural product (+)-goniodiol (II).
Journal of the Chemical Society, Perkin Transactions 1