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dc.contributor.convenorKaren A. Steidingeren_US
dc.contributor.authorA. McKenzie, Rossen_US
dc.contributor.authorA. Seawright, Alanen_US
dc.contributor.authorA. Wickramasinghe, Wasaen_US
dc.contributor.authorK. Eaglesham, Geoffen_US
dc.contributor.authorR. Moore, Michaelen_US
dc.contributor.authorR. Shaw, Glenen_US
dc.contributor.editorKaren A. Steidinger, Jan H. Landsberg, Carmelo R. Tomas, Gabriel A. Vargoen_US
dc.date.accessioned2017-04-04T14:20:07Z
dc.date.available2017-04-04T14:20:07Z
dc.date.issued2004en_US
dc.date.modified2014-06-11T01:13:41Z
dc.identifier.urihttp://hdl.handle.net/10072/22851
dc.identifier.urihttp://research.myfwc.com/features/view_article.asp?id=25973en_US
dc.description.abstractThe cyanobacterial toxin cylindrospermopsin is produced by Cylindrospermopsis raciborskii and Aphanizomenon ovalisporum in many parts of the world. A human poisoning incident occurring at Palm Island, Queensland, Australia in 1979 was subsequently ascribed to cylindrospermopsin. The structure of cylindrospermopsin, a tricyclic guanidinium moiety bridged to hydroxymethyluracil, was deduced in 1992. A number of studies have investigated the acute toxicity of cylindrospermopsin in mice. It is primarily a hepatotoxin with a 24-hour acute intraperitoneal (IP) LD50 of 2 mg/kg, a 5-day acute i.p. LD50 of 0.2 mg/kg and a 5-day acute oral LD50 of approximately 6 mg/kg. A human health risk assessment using data from longer-term oral dosing studies suggests a guideline value for cylindrospermopsin in drinking water of approximately 10 姯L.We have recently studied cattle poisonings by cylindrospermopsin and detected the toxin in a number of tissues after necropsy. Concentrations of 1 mg/L or above in drinking water (dose is approximately 50 姯kg/day) were shown to result in cattle death after short-term exposure (less than 10 days). Oral dosing of mice at levels up to 5 mg/L with cylindrospermopsin in drinking water for 90 days did not produce any significant toxicity. Human health risk assessment based on cattle however, which are much more sensitive to cylindrospermopsin than rodents, would produce a guideline for human drinking water of approximately 0.05 姯L. A consideration of reported human poisoning incidents that implicate cylindrospermopsin suggests that humans may also be more sensitive than rodents to this toxin.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent57065 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherFlorida Fish and Wildlife Conservation Commission, Florida Institute of Oceanography, and UNESCOen_US
dc.publisher.placeSt. Petersburg, Florida, USAen_US
dc.publisher.urihttp://www.issha.org/Welcome-to-ISSHA/Conferences/ICHA-Conferences/Past-conferencesen_US
dc.relation.ispartofconferencenameXth International Conference on Harmful Algaeen_US
dc.relation.ispartofconferencetitleHarmful Algae 2002en_US
dc.relation.ispartofdatefrom2002-10-21en_US
dc.relation.ispartofdateto2002-10-25en_US
dc.relation.ispartoflocationSt. Pete Beach, Florida, USAen_US
dc.subject.fieldofresearchcode321201en_US
dc.titleComparative toxicity of the cyanobacterial toxin cylindrospermopsin between mice and cattle: human implicationsen_US
dc.typeConference outputen_US
dc.type.descriptionE1 - Conference Publications (HERDC)en_US
dc.type.codeE - Conference Publicationsen_US
gro.rights.copyrightCopyright 2002 ISSH. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the conference's website for access to the definitive, published version.en_US
gro.date.issued2004
gro.hasfulltextFull Text


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