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dc.contributor.convenorKaren A. Steidinger
dc.contributor.authorShaw, Glen R.
dc.contributor.authorMcKenzie, Ross A.
dc.contributor.authorWickramasinghe, Wasa A.
dc.contributor.authorSeawright, Alan A.
dc.contributor.authorEaglesham, Geoff K.
dc.contributor.authorMoore, Michael R.
dc.contributor.editorKaren A. Steidinger, Jan H. Landsberg, Carmelo R. Tomas, Gabriel A. Vargo
dc.date.accessioned2017-05-03T11:10:44Z
dc.date.available2017-05-03T11:10:44Z
dc.date.issued2004
dc.date.modified2014-06-11T01:13:41Z
dc.identifier.urihttp://hdl.handle.net/10072/22851
dc.description.abstractThe cyanobacterial toxin cylindrospermopsin is produced by Cylindrospermopsis raciborskii and Aphanizomenon ovalisporum in many parts of the world. A human poisoning incident occurring at Palm Island, Queensland, Australia in 1979 was subsequently ascribed to cylindrospermopsin. The structure of cylindrospermopsin, a tricyclic guanidinium moiety bridged to hydroxymethyluracil, was deduced in 1992. A number of studies have investigated the acute toxicity of cylindrospermopsin in mice. It is primarily a hepatotoxin with a 24-hour acute intraperitoneal (IP) LD50 of 2 mg/kg, a 5-day acute i.p. LD50 of 0.2 mg/kg and a 5-day acute oral LD50 of approximately 6 mg/kg. A human health risk assessment using data from longer-term oral dosing studies suggests a guideline value for cylindrospermopsin in drinking water of approximately 10 姯L.We have recently studied cattle poisonings by cylindrospermopsin and detected the toxin in a number of tissues after necropsy. Concentrations of 1 mg/L or above in drinking water (dose is approximately 50 姯kg/day) were shown to result in cattle death after short-term exposure (less than 10 days). Oral dosing of mice at levels up to 5 mg/L with cylindrospermopsin in drinking water for 90 days did not produce any significant toxicity. Human health risk assessment based on cattle however, which are much more sensitive to cylindrospermopsin than rodents, would produce a guideline for human drinking water of approximately 0.05 姯L. A consideration of reported human poisoning incidents that implicate cylindrospermopsin suggests that humans may also be more sensitive than rodents to this toxin.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent57065 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherFlorida Fish and Wildlife Conservation Commission, Florida Institute of Oceanography, and UNESCO
dc.publisher.placeSt. Petersburg, Florida, USA
dc.publisher.urihttps://issha.org/
dc.relation.ispartofconferencenameXth International Conference on Harmful Algae
dc.relation.ispartofconferencetitleHarmful Algae 2002
dc.relation.ispartofdatefrom2002-10-21
dc.relation.ispartofdateto2002-10-25
dc.relation.ispartoflocationSt. Pete Beach, Florida, USA
dc.subject.fieldofresearchcode321201
dc.titleComparative toxicity of the cyanobacterial toxin cylindrospermopsin between mice and cattle: human implications
dc.typeConference output
dc.type.descriptionE1 - Conferences
dc.type.codeE - Conference Publications
gro.rights.copyright© 2002 ISSH. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the conference's website for access to the definitive, published version.
gro.date.issued2004
gro.hasfulltextFull Text
gro.griffith.authorShaw, Glendon R.


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