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dc.contributor.authorKyd, Jennelle M
dc.contributor.authorCripps, Allan W
dc.contributor.editorDr. R E Spier
dc.date.accessioned2017-05-03T16:56:22Z
dc.date.available2017-05-03T16:56:22Z
dc.date.issued2008
dc.date.modified2011-10-10T06:15:24Z
dc.identifier.issn0264-410X
dc.identifier.doi10.1016/j.vaccine.2008.09.061
dc.identifier.urihttp://hdl.handle.net/10072/23279
dc.description.abstractOral delivery of agents such as vaccines offers a number of significant advantages over parenteral routes, yet only a small number of oral vaccines are routinely available today. The small intestine contains lymphoid aggregates that are overlaid by M cells. These aggregates are part of the gut-associated lymphoid tissues and are important for determining host responses to particulate antigenic material within the small intestine. Differentiating the receptor requirements for M cell uptake and transcytosis of bacterial antigen from the intestine has progressed although the specific signalling mechanisms that initiate antigen uptake and specifically target antigen to these cells is still relatively unknown. Microbial pathogen-associated molecular patterns (PAMPs) are recognised by the innate immune system through pattern recognition receptors (PRRs) either through direct receptor-bacterial ligand or endogenous adaptor-bacterial molecule interactions. PRRs on the surface of M cells that have been identified as important in antigen transcytosis include toll-like receptor-4, platelet-activating factor receptor and a5߱ integrin. A number of these PRRs are also found on neighbouring enterocytes and therefore the pathways signalled by receptor-ligand binding may differentially trigger different transduction pathways. Elucidation of these signalling pathways may assist in the design of effective oral vaccines that target the gut-associated lymphoid tissue.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent790853 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom6221
dc.relation.ispartofpageto6224
dc.relation.ispartofissue49
dc.relation.ispartofjournalVaccine
dc.relation.ispartofvolume26
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320499
dc.titleFunctional differences between M cells and enterocytes in sampling luminal antigens
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2008 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorCripps, Allan W.


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