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  • Investigation of the NOTCH3 and TNFSF7 Genes on C19p13 as Candidates for Migraine

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    Author(s)
    Smith, Robert
    Curtain, Rob
    Ovcaric, Micky
    Tajouri, Lotfi
    MacMillan, John
    Griffiths, Lyn
    Griffith University Author(s)
    MacMillan, John C.
    Tajouri, Lotfi
    Griffiths, Lyn
    Curtain, Rob
    Smith, Robert A.
    Ovcaric, Micky
    Year published
    2008
    Metadata
    Show full item record
    Abstract
    To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2- p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13), homologous to the ligands of TNF-alpha and TNF-beta, genes that have previously been associated with migraine. The NOTCH3 gene was analysed by sequencing all exons with known CADASIL mutations in a typical (non-familial hemiplegic) migraine family (MF1) that has previously been shown to be linked to C19p13. The TNFSF7 gene was investigated through SNP association analysis using a matched case-control migraine population. NOTCH3 ...
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    To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2- p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13), homologous to the ligands of TNF-alpha and TNF-beta, genes that have previously been associated with migraine. The NOTCH3 gene was analysed by sequencing all exons with known CADASIL mutations in a typical (non-familial hemiplegic) migraine family (MF1) that has previously been shown to be linked to C19p13. The TNFSF7 gene was investigated through SNP association analysis using a matched case-control migraine population. NOTCH3 gene sequencing results for affected members of MF1 proved to be negative for all known sequence variants giving rise to mutations for CADASIL. TNFSF7 gene chisquare results showed non-significant P values across all populations tested against controls, except for the MO subgroup which displayed a possible association with the TNFSF7 SNP (genotype, allele analysis P = 0.036, P = 0.017 respectively). Our results suggest that common migraine is not caused by any known CADASIL mutations in the NOTCH3 gene of interest. However, the TNFSF7 gene displayed signs of involvement in a MO affected population and indicates that further independent studies of this marker are warranted.
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    Journal Title
    The Open Neurology Journal
    Volume
    2
    Publisher URI
    http://www.benthamscience.com/open/toneuj/index.htm
    Copyright Statement
    © The Author(s) 2008. For information about this journal please refer to the publisher's website or contact the authors. Articles are licensed under the terms of the Creative Commons Attribution non-commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Genomics
    Central Nervous System
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/23283
    Collection
    • Journal articles

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