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  • Immunodeficiency-associated lymphomas

    Author(s)
    Tran, Huy
    Nourse, Jamie
    Hall, Sara
    Green, Michael
    Griffiths, Lyn
    Gandhi, Maher K
    Griffith University Author(s)
    Griffiths, Lyn
    Green, Michael R.
    Year published
    2008
    Metadata
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    Abstract
    This article covers lymphoproliferative disorders in patients with primary or acquired immunodeficiencies. Primary immunodeficiences include Ataxia Telangiectasia and X-linked disorders such as Wiskott-Aldrich syndrome. Acquired immunodeficiencies predominantly occur in the setting of infection with the Human Immunodeficiency Virus or arise following immunosuppressive therapy administered after organ transplantation. The rising incidence of HIV throughout the world and the dramatic increase in transplant surgery since the 1990's suggest that these lymphomas will remain an important health problem. Evidence for lymphoma ...
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    This article covers lymphoproliferative disorders in patients with primary or acquired immunodeficiencies. Primary immunodeficiences include Ataxia Telangiectasia and X-linked disorders such as Wiskott-Aldrich syndrome. Acquired immunodeficiencies predominantly occur in the setting of infection with the Human Immunodeficiency Virus or arise following immunosuppressive therapy administered after organ transplantation. The rising incidence of HIV throughout the world and the dramatic increase in transplant surgery since the 1990's suggest that these lymphomas will remain an important health problem. Evidence for lymphoma developing as a result of treatment with methotrexate or Tumour Necrosis Factor Antagonists for autoimmune entities will also be reviewed. The lymphoproliferations that occur with immunodeficiency are extremely heterogenous. In part this reflects the diversity of the causal immune defect. The most striking clinical characteristic is the high frequency of extranodal disease. Frequently, these lymphomas are driven by viruses such as Epstein-Barr virus (EBV), although the lack of EBV in a proportion indicates that alternate pathways must also be involved in the pathogenesis. Lastly, discussion will centre on mechanisms utilized by lymphomas in the immunodeficient as these may have applications to lymphomas in the ''immunocompetent'', by serving as a paradigm for the altered immunoregulatory environment present in many lymphoma sub-types.
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    Journal Title
    Blood Reviews
    Volume
    22
    DOI
    https://doi.org/10.1016/j.blre.2008.03.009
    Subject
    Cardiovascular medicine and haematology
    Clinical sciences
    Immunogenetics (incl. genetic immunology)
    Publication URI
    http://hdl.handle.net/10072/23298
    Collection
    • Journal articles

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