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  • Investigation between the S377G3 GATA-4 polymorphism and migraine

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    Author(s)
    Chikhani, Sherin
    Fernandez, Francesca
    Karl, Poetter
    Brendan, Toohey
    Harvey, Richard
    Griffiths, Lyn
    Griffith University Author(s)
    Griffiths, Lyn
    Chikhani, Sherin
    Fernandez, Francesca
    Year published
    2008
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    Abstract
    Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino ...
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    Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (???????????? = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.
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    Journal Title
    The open Neurology Journal
    Volume
    2
    Publisher URI
    http://www.bentham.org/open/toneuj/index.htm
    Copyright Statement
    © The Author(s) 2008. For information about this journal please refer to the publisher's website or contact the author[s]. Articles are licensed under the terms of the Creative Commons Attribution non-commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/23299
    Collection
    • Journal articles

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