Show simple item record

dc.contributor.authorLoiselle, D.en_US
dc.contributor.authorCrampin, E.en_US
dc.contributor.authorNiederer, S.en_US
dc.contributor.authorSmith, N.en_US
dc.contributor.authorBarclay, Chrisen_US
dc.contributor.editorDenis Nobleen_US
dc.date.accessioned2017-04-24T08:34:40Z
dc.date.available2017-04-24T08:34:40Z
dc.date.issued2008en_US
dc.date.modified2011-11-01T06:55:00Z
dc.identifier.issn00796107en_US
dc.identifier.doi10.1016/j.pbiomolbio.2008.02.015en_AU
dc.identifier.urihttp://hdl.handle.net/10072/23309
dc.description.abstractIn this brief review, we have focussed largely on the well-established, but essentially phenomenological, linear relationship between the energy expenditure of the heart (commonly assessed as the oxygen consumed per beat, oxygen consumption (VO2)) and the pressure-volume-area (PVA, the sum of pressure-volume work and a specified 'potential energy' term). We raise concerns regarding the propriety of ignoring work done during 'passive' ventricular enlargement during diastole as well as the work done against series elasticity during systole. We question the common assumption that the rate of basal metabolism is independent of ventricular volume, given the equally well-established Feng- or stretcheffect. Admittedly, each of these issues is more of conceptual than of quantitative import. We point out that the linearity of the enthalpy-PVA relation is now so well established that observed deviations from linearity are often ignored. Given that a one-dimensional equivalent of the linear VO2 PVA relation exists in papillary muscles, it seems clear that the phenomenon arises at the cellular level, rather than being a property of the intact heart. This leads us to discussion of the classes of crossbridge models that can be applied to the study of cardiac energetics. An admittedly superficial examination of the historical role played by Hooke's Law in theories of muscle contraction foreshadows deeper consideration of the thermodynamic constraints that must, in our opinion, guide the development of any mathematical model. We conclude that a satisfying understanding of the origin of the enthalpy-PVA relation awaits the development of such a model.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom348en_US
dc.relation.ispartofpageto366en_US
dc.relation.ispartofissue2-3en_US
dc.relation.ispartofjournalProgress in Biophysics and Molecular Biologyen_US
dc.relation.ispartofvolume97en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchAnimal Physiology - Cellen_US
dc.subject.fieldofresearchcode060602en_US
dc.titleEnergetic consequences of mechanical loadsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record