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dc.contributor.authorRupf, S.en_US
dc.contributor.authorHannig, M.en_US
dc.contributor.authorSchellenberger, W.en_US
dc.contributor.authorBreitung, K.en_US
dc.contributor.authorEschrich, K.en_US
dc.contributor.authorRemmerbach, Torstenen_US
dc.contributor.authorKneist, S.en_US
dc.date.accessioned2017-05-03T15:18:42Z
dc.date.available2017-05-03T15:18:42Z
dc.date.issued2008en_US
dc.date.modified2011-10-19T07:26:03Z
dc.identifier.issn00220345en_US
dc.identifier.doi10.1177/154405910808701203en_AU
dc.identifier.urihttp://hdl.handle.net/10072/23329
dc.description.abstractInformation concerning phenotypic heterogeneity of Streptococcus mutans in carious dentin is sparse. Matrix-assisted laser-desorption/ionizationtime- of-flight mass-spectrometry (MALDI-TOFMS) facilitates the phenotypic differentiation of bacteria to the subspecies level. To verify a supposed influence of restorative treatment on the phenotypic heterogeneity of S. mutans, we isolated and compared a total of 222 S. mutans strains from dentin samples of 21 human deciduous molars during caries excavation (T1) and 8 wks (T2) after removal of the temporary restoration. Phenotypic heterogeneity was determined by MALDI-TOF-MS and hierarchical clustering. Thirty-six distinct S. mutans phenotypes could be identified. Although indistinguishable phenotypes were found in the same teeth at T1 and T2, as well as in different teeth of individual participants, the phenotypic heterogeneity increased significantly, from 1.4 phenotypes per S. mutans-positive dentin sample at T1 to 2.2 phenotypes at T2. We attribute this to an adaptation of S. mutans to the modified environment under the restoration following caries excavation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherInternational & American Associations for Dental Researchen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1172en_US
dc.relation.ispartofpageto1176en_US
dc.relation.ispartofissue12en_US
dc.relation.ispartofjournalJournal of dental researchen_US
dc.relation.ispartofvolume87en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchDentistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode110599en_US
dc.titlePhenotypic Heterogeneity of Streptococcus mutans in Dentinen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorRemmerbach, Torsten W.


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