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dc.contributor.authorVanderlelie, Jessicaen_US
dc.contributor.authorGude, N.en_US
dc.contributor.authorPerkins, Anthonyen_US
dc.date.accessioned2017-05-03T11:16:53Z
dc.date.available2017-05-03T11:16:53Z
dc.date.issued2008en_US
dc.date.modified2009-09-17T07:23:07Z
dc.identifier.issn0143-4004en_US
dc.identifier.doi10.1016/j.placenta.2008.02.016en_AU
dc.identifier.urihttp://hdl.handle.net/10072/23374
dc.description.abstractOxidative stress has been implicated in the pathogenesis of preeclampsia. This study measured the relative mRNA expression of antioxidant proteins glutathione peroxidase 1 and 4, glutathione reductase, thioredoxin 1 and 2, thioredoxin reductase 1, thioredoxin peroxidase 3 and superoxide dismutase 1 and 2 in preeclamptic and non-preeclamptic placentae. Quantitative real-time PCR was conducted on placental mRNA isolated from preeclamptic and control patients. Cycle threshold numbers and fold differences were calculated as a measure of linear product amplification and used for comparison. The mRNA expression of glutathione reductase was significantly reduced (fold difference 0.41, p<0.05) in preeclamptic placenta when compared to controls while the expression of thioredoxin peroxidase 3 was significantly increased (fold difference 3.25, p<0.001) in the preeclamptic placentae. No significant difference in expression was observed for glutathione peroxidase 1 and 4, thioredoxin 1 and 2, thioredoxin reductase 1 and superoxide dismutase 1 and 2. These results suggest that it is the abnormal oxidative insult associated with preeclampsia not mRNA expression of antioxidant proteins that may be responsible for reduced antioxidant enzyme activity in preeclamptic placentae.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeHollanden_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom519en_US
dc.relation.ispartofpageto522en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalPlacentaen_US
dc.relation.ispartofvolume29en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270199en_US
dc.titleAntioxidant Gene Expression in Preeclamptic Placentae: A Preliminary Investigationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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