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dc.contributor.authorJ. Liu, Johnsonen_US
dc.contributor.authorGalettis, Peteren_US
dc.contributor.authorFarr, Alistairen_US
dc.contributor.authorMaharaj, Lenushkaen_US
dc.contributor.authorSamarasinha, Hasithaen_US
dc.contributor.authorC. McGechan, Adamen_US
dc.contributor.authorC. Baguley, Bruceen_US
dc.contributor.authorBerners-Price, Sueen_US
dc.contributor.authorJ. McKeage, Marken_US
dc.contributor.editorDr. J H Dawson (Editor-in-Chief)en_US
dc.date.accessioned2017-05-03T16:56:53Z
dc.date.available2017-05-03T16:56:53Z
dc.date.issued2008en_US
dc.date.modified2012-05-23T22:03:39Z
dc.identifier.issn01620134en_US
dc.identifier.doi10.1016/j.jinorgbio.2007.09.003en_US
dc.identifier.urihttp://hdl.handle.net/10072/23449
dc.description.abstractIn this study we characterised the in vitro antitumour and hepatotoxicity profiles of a series of Au(I) and Ag(I) bidentate phenyl and pyridyl complexes in a panel of cisplatin-resistant human ovarian cancer cell-lines, and in isolated rat hepatocytes. The gold and silver compounds overcame cisplatin-resistance in the CH1-cisR, 41M-cisR and SKOV-3 cell-lines, and showed cytotoxic potencies strongly correlated with their lipophilicity. Complexes with phenyl or 2-pyridyl ligands had high antitumour and hepatotoxic potency and low selectivity between different cell-lines. Their cytotoxicity profiles were similar to classic mitochondrial poisons and an example of this type of compound was shown to accumulate preferentially in the mitochondria of cancer cells in a manner that depended upon the mitochondrial membrane potential. In contrast, complexes with 3- or 4-pyridyl ligands had low antitumour and hepatotoxic potency and cytotoxicity profiles similar to 2-deoxy-D-glucose. In addition, they showed high selectivity between different cell-lines that was not attributable to variation in uptake in different cell-types. The in vitro hepatotoxic potency of the series of gold and silver compounds varied by over 61-fold and was closely related to their lipophilicity and hepatocyte uptake. In conclusion, Au(I) and Ag(I) bidendate pyridyl phosphine complexes demonstrate activity against cisplatin-resistant human cancer cells and in vitro cytotoxicity that strongly depends upon their lipophilicity. 頲007 Elsevier Inc. All rights reserved.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevier Inc.en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom303en_US
dc.relation.ispartofpageto310en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalJournal of Inorganic Biochemistryen_US
dc.relation.ispartofvolume102en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060199en_US
dc.titleIn vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptakeen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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