dc.contributor.author | Liu, Johnson J | |
dc.contributor.author | Galettis, Peter | |
dc.contributor.author | Farr, Alistair | |
dc.contributor.author | Maharaj, Lenushka | |
dc.contributor.author | Samarasinha, Hasitha | |
dc.contributor.author | McGechan, Adam C | |
dc.contributor.author | Baguley, Bruce C | |
dc.contributor.author | Bowen, Richard J | |
dc.contributor.author | Berners-Price, Susan J | |
dc.contributor.author | McKeage, Mark J | |
dc.contributor.editor | Dr. J H Dawson (Editor-in-Chief) | |
dc.date.accessioned | 2018-02-13T03:37:09Z | |
dc.date.available | 2018-02-13T03:37:09Z | |
dc.date.issued | 2008 | |
dc.date.modified | 2012-05-23T22:03:39Z | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2007.09.003 | |
dc.identifier.uri | http://hdl.handle.net/10072/23449 | |
dc.description.abstract | In this study we characterised the in vitro antitumour and hepatotoxicity profiles of a series of Au(I) and Ag(I) bidentate phenyl and pyridyl complexes in a panel of cisplatin-resistant human ovarian cancer cell-lines, and in isolated rat hepatocytes. The gold and silver compounds overcame cisplatin-resistance in the CH1-cisR, 41M-cisR and SKOV-3 cell-lines, and showed cytotoxic potencies strongly correlated with their lipophilicity. Complexes with phenyl or 2-pyridyl ligands had high antitumour and hepatotoxic potency and low selectivity between different cell-lines. Their cytotoxicity profiles were similar to classic mitochondrial poisons and an example of this type of compound was shown to accumulate preferentially in the mitochondria of cancer cells in a manner that depended upon the mitochondrial membrane potential. In contrast, complexes with 3- or 4-pyridyl ligands had low antitumour and hepatotoxic potency and cytotoxicity profiles similar to 2-deoxy-D-glucose. In addition, they showed high selectivity between different cell-lines that was not attributable to variation in uptake in different cell-types. The in vitro hepatotoxic potency of the series of gold and silver compounds varied by over 61-fold and was closely related to their lipophilicity and hepatocyte uptake. In conclusion, Au(I) and Ag(I) bidendate pyridyl phosphine complexes demonstrate activity against cisplatin-resistant human cancer cells and in vitro cytotoxicity that strongly depends upon their lipophilicity. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 303 | |
dc.relation.ispartofpageto | 310 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Journal of Inorganic Biochemistry | |
dc.relation.ispartofvolume | 102 | |
dc.relation.uri | http://purl.org/au-research/grants/ARC/DP0452327 | |
dc.relation.grantID | DP0452327 | |
dc.relation.funders | ARC | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Inorganic chemistry | |
dc.subject.fieldofresearch | Theoretical and computational chemistry | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearch | Biochemistry and cell biology not elsewhere classified | |
dc.subject.fieldofresearchcode | 3402 | |
dc.subject.fieldofresearchcode | 3407 | |
dc.subject.fieldofresearchcode | 3499 | |
dc.subject.fieldofresearchcode | 310199 | |
dc.title | In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2008 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Berners-Price, Sue J. | |